Drug Discovery and OTC's

Question 1

Example of Rational Drug Design

Answer 1

Ritonavir, a HIV-1 protease inhibitor based on protease specificity/3d structure, designed to fit in active site

Question 2

2 Aspects of Screening Compound Libraries

Answer 2

Combinatorial chemistry to allow for create of large libraries of substances from precursor copounds with common functional groups by adding divergent side chains
High Throughput Screening: robotic automation that allows screening of thousands of compounds quickly. Needs assay that can be automated

Question 3

3 Steps of Drug Discovery

Answer 3

Hit: compound that passes drug screen
Lead Compound: Compound that shows promise after further biological, physiochemical, and pharmacological characteriziation
Lead Optimization: Candidate modified based on that shit’s information obtained during drug development

Question 4

IND

Answer 4

Investigational New Drug Application after drug development/preclinical studies needed to begin clinical trials

Question 5

Crossover Method

Answer 5

Each subject gets period of test drug, placebo, and standard treatment

Question 6

NDA

Answer 6

New Drug Application, includes all trials and is required to market drug

Question 7

2 Kinds of Patents

Answer 7

Composition of Matter Patent: standard drug patent for a novel compound that is efficacious
Use Patent: New, non obvious therapeutic use for a previously known chemical entity