*inflammatory and antigout drugs Flashcards
what are all the therapeutic affects that NSAIDs have
analgesic, anti-inflammatory, antipyretic, aspirin-platelet inhibition
what drug class is aspirin in
salicylates
what class does diclofenac sodium, indomethacin, keorolac belong to
acetic acid derivatives
what class is celecoxib
COX-2 inhibitors
propionic acid derivatives drug example
ibuprofen, naproxen
what drug is shown to reduce cardiac death after MI
aspirin
what is the general MOA of NSAIDs
inhibition of leukotriene pathway, prostaglandin pathway or both
what is the MOA of COX inhibitors
COX-2 promotes synthesis of prostaglands involved in inflammatory processes
is aspirin a COX-1 or COX-2 receptor inhibitor
COX-1 receptor inhibitor in platelets and reduces platelet agrigation
misoprostol benefits for taking NSAIDs
prevents GI bleed, inhibits gastric acid secretion
how do NSAIDs affect kidney function
disruption of prostaglandin function can cause acute or chronic kidney failure
why can’t children take asprin
reyes syndrome
reyes syndrome effects
neurological deficits and liver damage
what is indomethacin used for
RA, OA, tendonitis, gout
what is ketorolac and what is it used for
mostly analgesia, but some anti-inflammatory used with morphine
