*heart failure drugs Flashcards

1
Q

what is inotropic

A

heart contraction

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2
Q

what is chronotropic

A

heart rate

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3
Q

what is dromotropic

A

speed of electrical impulse

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4
Q

what are the symptoms of left sided heart failure

A

pulmonary edna, coughing, SOB, dyspnea, systolic= decreased contractility, diastolic= unable to relax

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5
Q

what are the symptoms of right sided heart failure

A

systemic venous congestion, pedal edema, JVD, ascites, hepatic congestion

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6
Q

consequences of HF

A

blood supply to organs reduced, impaired kidney filtration leads to kidney injury/failure, pulmonary edema leads to SOB and peripheral edema

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7
Q

what do positive inotropic drugs do

A

increase force of contraction

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8
Q

what do positive chronotropic drugs do

A

increase HR

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9
Q

what do positive dromotropic drugs do

A

accelerate cardiac conduction

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10
Q

what do negative inotropic drugs do

A

decrease force of contration

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11
Q

what to negative chronotropic drugs do

A

decrease HR

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12
Q

what do negative dromotropic drugs do

A

decrease cardiac conduction

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13
Q

what are the drugs of choice for HF

A

lisinopril, valsartan and metoprolol

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14
Q

when is digoxin used in regards to other medications

A

after the drugs of choice for heart failure are used

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15
Q

what positive inotropic drug is used for early treatment of HF

A

dobutamine

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16
Q

what drug class is lisinopril

A

ACE inhibitor

17
Q

what drugs prevents cardiac moddeling

A

lisinopril

18
Q

what drug class is valsartan

19
Q

what drug class is metoprolol

A

beta blocker

20
Q

which class causes diuresis which decreases blood volume and blood return to heart

A

ACE inhibitor

21
Q

what class causes vasodilatation that decreases systemic vascular resistance

22
Q

which two classes are effective in slowing ventricular remodelling and hypertrophy

A

ACE and ARBs

23
Q

which drug class stop catecholamine mediated actions on the heart

A

beta blockers

24
Q

miscellaneous drug that treats HF

A

dobutamine

25
phosphodiesterase inhibitors MOA
inhibits the enzyme phosphodiesterase to have a positive inotropic effect
26
what drug class is milrinone
phosphodiesterase inhibitors
27
what duration of time is milrinone not supposed to be used for
long term use
28
what cannot be administered IV with milrinone
furosemide
29
what is the prototype of cardiac glycosides
digoxin
30
what is the MOA of cardiac glycosides
increase myocardial contractility by changing the electrical conduction properties of the heart
31
what type of effect does digoxin have on the heart (one of the three effects)
positive inotropic effect
32
what indicates digoxin toxicity
most adverse effects signs and symptoms
33
what is digoxin immune fab therapy used for
hyperkalemia, cardiac dysthymias and digoxin overdose
34
what food in large amounts negatively effects the absorption of oral digoxin
bran
35
what reduces digoxin levels
ginseng, hawthorn and st johns wort