inflammation and repair Flashcards
rubor
redness
calor
increased heat
tumor
swelling
dolor
pain
function laesa
loss of function
exudate contains
fluids, fibrin and thrombocytes, and cells
transudate contains
low protein content, few cells
neutrophils
ICAM, important in first day, respond quickly to chemokines
macrophages
VCAM, important after first day and second day, longer survival and proliferation in tissue
chemotaxis
locomotion along a chemical gradient
IL-8
chemotactic for neutrophils and produced immediately
MCP-1
chemotactic for monocytes and macrophages, and produced after 24h
MPO
lysosomal enzyme
cytokines
TNF and IL-1, acute response and cause leukocyte production
monocytes
turn into macrophages when they enter a tissue
M1 macrophages
production of cytokines and growth factors
M2 macrophages
anti-inflammatory/wound repair and fibrosis
granulomatous inflammation
one of the strongest chronic inflammatory reactions,
fibrosis
abnormal wound healing in internal organs, excess deposition of ECM and scar tissue
elastin
gives elasticity to ECM
proteoglycans
negatively charged, bind water and give volume to ECM
collagens
strong fibrils, give strength to ECM
myofibroblast
activated fibroblast, produce proteins of ECM
PDGF and FGP
migration and proliferation of fibroblasts
