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-pharm Final > Inflammation > Flashcards

Inflammation Flashcards

1
Q

What drug class is aspirin in?

A

Salicylates

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2
Q

What is the action of aspirin?

A

Inhibits prostaglandins, blocks pain receptors and antipyretic

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3
Q

What is aspirin used for?

A

Rheumatoid disorders, osteoarthritis, and spondyloarthropathies

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4
Q

What are the SE’s of aspirin?

A

GI (N/V/D, heart burn, dyspepsia, epigastric discomfort)
Potential GI bleed, bruising, petichae s ulcers
Acute toxicity and ASA toxicity

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5
Q

Aspirin
What are the signs of acute toxicity?

A

Respiratory alkalosis,hypernea, tachypnea, PE, confusion, seizures, coma and cardiac arrest

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6
Q

Aspirin
What are signs of ASA toxicity?

A

TINNITUS***, hyperventilation, tachycardia, HTN

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7
Q

There is a black box warning for aspirin, why?
What are they symptoms of it?

A

Reyes syndrome (symptoms: brain encephalopathy, fatty liver, and hepatic damage)
it can also cause stillbirth/ fetal hemorrhage when it crosses the placenta

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8
Q

What are the patient teaching for aspirin?

A

No ETOH, do not crush or chew, watch for toxicity

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9
Q

What drug class is acetometaphen (APAP/Tylenol) in?

A

Analgesic antipyretic

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10
Q

How do we administer APAP?

A

IV and PO

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11
Q

What is the action of APAP?

A

Antipyretic, acts on hypothalamus, increases vasodilation and sweating (reduces fever)
Analgesic (diminishes pain)

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12
Q

Why do we give APAP to children?

A

Given after immunizations to reduce pain and fever

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13
Q

What are the SE’s of Acetometaphen (Tylenol)?

A

* Liver toxicity** (People who are suicidal will take a lot of Tylenol to OD from liver failure)
* Renal failure (drug accumulates and causes necrosis)
* Myocardial damage from high doses (5-8 g/day)

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14
Q

What should the nurse monitor when administering Acetometaphen (Tylenol)?

A
  • Jaundice
  • AST/ALT elevation
  • BUN/Cr levels
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15
Q

What are the antidote for Acetometaphen (Tylenol)?

A
  • activated charcoal, inhibits absorption
  • acetylcysteine (Mucolytics, oral and IV)
    - does not reverse damage already done
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16
Q

What herbs should patients not consume while taking APAP?

A

Willow, meadow root, Ginkob

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17
Q

What drug class is Prednisone in?

A

Exogenous corticosteroids

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18
Q

What is the action of prednisone?
What spectrum is it?

A

Decrease inflammation and inhibits tissue repair
Broad spectrum (+/-)

19
Q

Why do we give Prednisone?

A

Control symptoms but does not cure
Used for allergies, arthritis, asthma, cancer (immune suppression), COPD, inflammatory bowel, spinal cord injury, shock, acute renal cortical insufficiency

20
Q

What are the SE’s of Prednisone?

A

**Cushingoids good (buffalo face), adrenal insufficiency, decreased immunity, CNS and cardiac effects

21
Q

What is the black box warning for prednisone?

A

Adrenal insufficiency death

22
Q

What are the contraindications of Prednisone

A

Fungal infections and immune compromised

23
Q

What are patient teachings with Prednisone?

A

Scheduled drug times

24
Q

What drug class is ibuprofen in?

A
  • NSAID
25
Q

What is the action of ibuprofen?

A

First gen: blocks Cox 1/2
Anti-inflammatory, antipyretic, analgesic

26
Q

What is ibuprofen used for?

A

Dysmennorhea, arthritis, initial attacks of gout

27
Q

What are the SE’s of ibuprofen?

A

Nephrotoxicity!! Dry mouth, GI (melena/hemoptysis)

28
Q

Why does ibuprofen have a black box warning?

A

Increased risk of cv thrombotic events
CVA and MI

29
Q

What do we monitor when we administer ibuprofen?

A

BUN/Cr levels and CBC for clotting times

30
Q

What do we tell our pts to do when taking ibuprofen?

A

Take with food and liquid

31
Q

What drug class is meloxicam in?

A
  • Oxicam derivative
32
Q

Why do we give meloxicam?

A

Arthritis (rheumatoid/osteo), hemodialysis (7.5 mg/day)

33
Q

What are the SE’s of Meloxicam?

A

,neuralgic (dizzy, HA, drowsy and insomnia)
N/V/D and dyspepsia
respiratory (dyspnea, makes asthma worse)
Hematologic (decreased platelets, anemia, decrease Hgb/Hct, edema)

34
Q

What is the black box warning of meloxicam? What are we watching for?

A

CV events and GI bleed
Watch for black tarry stools

35
Q

What are the contraindications of Meloxicam?

A

Aspirin allergy and post op pts

36
Q

What drug class is celecoxib (Celebrex) in?

A

Cox 2 inhibitor

37
Q

What is the action of celecoxib?

A

Only decreases inflammation and pain

38
Q

Why do we give celecoxib?

A

Arthritis, ankylosing spondylitis, acute pain, colon polyps, dysmenorrhea

39
Q

What are the SE’s of Celecoxib? ,

A

Heart attack, CVS, GI bleed
CNS (HA, dizzy, insomnia)
Dermatological (rash, pruritus, sweating, dry mucous membranes)

40
Q

What are the signs of anaphylactic shock in celecoxib?

A

Weight gain, edema itching, sore throat

41
Q

What is the black box warning for celecoxib?

A

Heart attacks

42
Q

What are the contraindications for celecoxib?

A

Known allergy sulfa, taking NSAID’s (forms ulcers) or aspirins (ASA toxic)

43
Q

How do we store the celecoxib medication?

A

In a light protected container

-pharm Final (14 decks)

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