Inflammation

Question 1

What drug class is aspirin in?

Answer 1

Salicylates

Question 2

What is the action of aspirin?

Answer 2

Inhibits prostaglandins, blocks pain receptors and antipyretic

Question 3

What is aspirin used for?

Answer 3

Rheumatoid disorders, osteoarthritis, and spondyloarthropathies

Question 4

What are the SE’s of aspirin?

Answer 4

GI (N/V/D, heart burn, dyspepsia, epigastric discomfort)
Potential GI bleed, bruising, petichae s ulcers
Acute toxicity and ASA toxicity

Question 5

Aspirin
What are the signs of acute toxicity?

Answer 5

Respiratory alkalosis,hypernea, tachypnea, PE, confusion, seizures, coma and cardiac arrest

Question 6

Aspirin
What are signs of ASA toxicity?

Answer 6

TINNITUS***, hyperventilation, tachycardia, HTN

Question 7

There is a black box warning for aspirin, why?
What are they symptoms of it?

Answer 7

Reyes syndrome (symptoms: brain encephalopathy, fatty liver, and hepatic damage)
it can also cause stillbirth/ fetal hemorrhage when it crosses the placenta

Question 8

What are the patient teaching for aspirin?

Answer 8

No ETOH, do not crush or chew, watch for toxicity

Question 9

What drug class is acetometaphen (APAP/Tylenol) in?

Answer 9

Analgesic antipyretic

Question 10

How do we administer APAP?

Answer 10

IV and PO

Question 11

What is the action of APAP?

Answer 11

Antipyretic, acts on hypothalamus, increases vasodilation and sweating (reduces fever)
Analgesic (diminishes pain)

Question 12

Why do we give APAP to children?

Answer 12

Given after immunizations to reduce pain and fever

Question 13

What are the SE’s of Acetometaphen (Tylenol)?

Answer 13

* Liver toxicity** (People who are suicidal will take a lot of Tylenol to OD from liver failure)
* Renal failure (drug accumulates and causes necrosis)
* Myocardial damage from high doses (5-8 g/day)

Question 14

What should the nurse monitor when administering Acetometaphen (Tylenol)?

Answer 14

• Jaundice
• AST/ALT elevation
• BUN/Cr levels

Question 15

What are the antidote for Acetometaphen (Tylenol)?

Answer 15

• activated charcoal, inhibits absorption
• acetylcysteine (Mucolytics, oral and IV)
  - does not reverse damage already done

Question 16

What herbs should patients not consume while taking APAP?

Answer 16

Willow, meadow root, Ginkob

Question 17

What drug class is Prednisone in?

Answer 17

Exogenous corticosteroids

Question 18

What is the action of prednisone?
What spectrum is it?

Answer 18

Decrease inflammation and inhibits tissue repair
Broad spectrum (+/-)

Question 19

Why do we give Prednisone?

Answer 19

Control symptoms but does not cure
Used for allergies, arthritis, asthma, cancer (immune suppression), COPD, inflammatory bowel, spinal cord injury, shock, acute renal cortical insufficiency

Question 20

What are the SE’s of Prednisone?

Answer 20

**Cushingoids good (buffalo face), adrenal insufficiency, decreased immunity, CNS and cardiac effects

Question 21

What is the black box warning for prednisone?

Answer 21

Adrenal insufficiency death

Question 22

What are the contraindications of Prednisone

Answer 22

Fungal infections and immune compromised

Question 23

What are patient teachings with Prednisone?

Answer 23

Scheduled drug times

Question 24

What drug class is ibuprofen in?

Answer 24

• NSAID

Question 25

What is the action of ibuprofen?

Answer 25

First gen: blocks Cox 1/2 Anti-inflammatory, antipyretic, analgesic

Question 26

What is ibuprofen used for?

Answer 26

Dysmennorhea, arthritis, initial attacks of gout

Question 27

What are the SE’s of ibuprofen?

Answer 27

Nephrotoxicity!! Dry mouth, GI (melena/hemoptysis)

Question 28

Why does ibuprofen have a black box warning?

Answer 28

Increased risk of cv thrombotic events CVA and MI

Question 29

What do we monitor when we administer ibuprofen?

Answer 29

BUN/Cr levels and CBC for clotting times

Question 30

What do we tell our pts to do when taking ibuprofen?

Answer 30

Take with food and liquid

Question 31

What drug class is meloxicam in?

Answer 31

- Oxicam derivative

Question 32

Why do we give meloxicam?

Answer 32

Arthritis (rheumatoid/osteo), hemodialysis (7.5 mg/day)

Question 33

What are the SE’s of Meloxicam?

Answer 33

,neuralgic (dizzy, HA, drowsy and insomnia) N/V/D and dyspepsia respiratory (dyspnea, makes asthma worse) Hematologic (decreased platelets, anemia, decrease Hgb/Hct, edema)

Question 34

What is the black box warning of meloxicam? What are we watching for?

Answer 34

CV events and GI bleed Watch for black tarry stools

Question 35

What are the contraindications of Meloxicam?

Answer 35

Aspirin allergy and post op pts

Question 36

What drug class is celecoxib (Celebrex) in?

Answer 36

Cox 2 inhibitor

Question 37

What is the action of celecoxib?

Answer 37

Only decreases inflammation and pain

Question 38

Why do we give celecoxib?

Answer 38

Arthritis, ankylosing spondylitis, acute pain, colon polyps, dysmenorrhea

Question 39

What are the SE’s of Celecoxib? ,

Answer 39

Heart attack, CVS, GI bleed CNS (HA, dizzy, insomnia) Dermatological (rash, pruritus, sweating, dry mucous membranes)

Question 40

What are the signs of anaphylactic shock in celecoxib?

Answer 40

Weight gain, edema itching, sore throat

Question 41

What is the black box warning for celecoxib?

Answer 41

Heart attacks

Question 42

What are the contraindications for celecoxib?

Answer 42

Known allergy sulfa, taking NSAID's (forms ulcers) or aspirins (ASA toxic)

Question 43

How do we store the celecoxib medication?

Answer 43

In a light protected container