immunology and disorders Flashcards
what are SPUR infections
serious, persistent, unusual, recurrent infections (most potent) that are signs of immune deficiency
which is more common primary or secondary immune deficiencies and what are they
secondary, PID = immune component missing
In PID’s, what is associetad with primary antibody deficiency and what are some examples
sinusitis and otitis pedia, CVID, specific AB def (SAD), X - linked agamma… (XLA)
who is likely to have complement system disorders
laryngeal angioedema
what can cause congenital neutropenias
IgG deficiency in children
what is kotsmann syndrome
neutrophils are not produced , rare autosomal dominant disease, count down, severe congenital neutropenia (SCN)
how can failure to produce neutrophils arise
failure of stem cell differentiation and failure to mature to neutrophils
what is leukocyte adhesion deficiency
PID, neutrophils can’t stick to vessels and enter to site of infection, autosomal recessive, count OK
what is chronic granulomatous disease (CGD)
failure of oxidase killing (NADPH complex) so neutrophils cannot kill, count OK, lots of pus
what can anti-TNF reactivate
latent TB
how o you treat PID’s
Ig replacement, bone marrow transplant, gene therapy
where do neutrophils arise
haematopoietic cells from bone marrow
what is reticular dysgenesis
stem cells can’t differentiate into haematopoietic cells
what is severe combined immune deficiency (SCID)
failure to produce lymphocytes
why does SCID only present after 3 months
maternal IgG boosts babies immunity until then
