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MSK > Immunology > Flashcards

Immunology Flashcards

1
Q

What drives autoimmunity?

A

Activation of auto-reactive T and B cells

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2
Q

What CD4+ cells are involved in RA?

A

Th1 and Th17

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3
Q

What kind of hypersensitivity reaction is MG?

A

Type II

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4
Q

What kind of hypersensitivity reaction is RA?

A

Type IV

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5
Q

What is rheumatic factor (RF)?

A

An autoantibody found in RA which attacks the Fc region of IgG

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6
Q

What is the pathophysiology of myasthenia gravis?

A

Autoimmune condition in which auto IgG binds to postsynaptic ACh receptors -> inhibits contraction

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7
Q

How do patients with MG typically present?

A

Eye drooping

Facial muscles are most commonly affected
Rarely neck, shoulders and hip

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8
Q

How do you diagnose myasthenia gravis?

A

Presence of anti-AChR IgG

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9
Q

What is the first line management for myasthenia gravis?

Why must this drug be carefully monitored?

A

Anti-cholinesterase agents
- Pyridostigmine

Can cause lots of side effects as increasing half life of ACh

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MSK (41 decks)

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