Immunology 6 Flashcards
These are lymphocytes that arise in the bone marrow and develop in thymus.
T cells
- remember that the thymus is the school for T cells. They develop and teach T cells to not react to self antigens. If T cells react to self antigens, this means that the immune system is immunocompromised.
What are the 2 main coreceptors of T cells?
CD4 and CD8
What are the 2 main coreceptors for T cells?
CD4 and CD8
What is TCR gene rearrangement?
It’s the T cell developing to recognise specific genes by having unique antigen receptors.
- remember each T cell has a TCR which will recognise specific antigens.
What are immature T cells called?
Thymocytes
This is the process when thymocytes rearrange the variable parts of their TCR genes in the thymus.
- this is a random process
- ensures that individual T cells are unique in terms of their TCR.
Thymus gene rearrangement
T cells express a _____ that recognises ______ and ____ on an APC (like dendritic cell)
T cell receptor; peptide; MHC
These molecules ASSIST with the docking of the TCR onto MHC II or MHC I
- so they help to ATTACH both TCR (which will activate the T cell) to the MHC on APC (which will present the antigen to B cells so B cells will be activated)
CD4 => MHC 2
CD8 => MHC 1
T cell differentiation is when T cells are:
ACTIVE
This is what you call T cells that have not been activated by MHC/peptide
Naive cells
_____ produced by CD4 T cells help CD8 T cells become activated. Why?
Cytokines. Cytokines facilitate the growth and activity of the immune system as well as stimulate the migration of cells to ALERT the T cells that there are pathogens and therefore stimulate an IMMUNE response.
CD8 T cells or cytotoxic lymphocytes cause what in cells?
Apoptosis/cell death
T cell activation results in the formation of these cells. They reside in the body for long periods of time and become faster effector cells.
Memory T cells
