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PPClues > Immunology > Flashcards

Immunology Flashcards

1
Q

Which cytokine do macrophages stimulate?

A

Il-1

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2
Q

Which cytokines do Th cells stimulate?

A

Everything other than Il-1

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3
Q

Which enlarged lymph nodes are most likely malignant?

A

Supraventricular
Epitrochlear
Inguinal

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4
Q

What is CD8?

A

Tk (killer) or Ts (suppressor) cell; responds to MHC-1 (self)

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5
Q

Which of your cells express MHC-1?

A

All except RBCs and platelets

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6
Q

What is a CD4?

A

Th (helper) cell; responds to MHC-2 (non-self)

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7
Q

What type of immunity does Th1 provide?

A

Cell-mediated

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8
Q

What type of immunity does TH2 provide?

A

Humoral

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9
Q

What do B cell deficiency patients die of?

A

Bacterial infection

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10
Q

What is Common Variable Hypogammaglobulinemia?

A

Kids w/ B cells don’t differentiate into plasma cells => low Ab

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11
Q

What is Bruton’s Agammaglobulinemia?

A

Young adults w/ defective Tyr kinase=> no Ab, X-linked

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12
Q

What is Job-Buckley Syndrome?

A

Redheaded females, stuck in IgE stage

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13
Q

What is Multiple Myeloma?

A

Multiple osteolytic lesions, IgG, n light chains, rouleaux

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14
Q

What is Heavy Chain Disease?

A

IgA and multiple myeloma of GI tract

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15
Q

What is Selective IgG2 Deficiency?

A

Recurrent encapsulated infections

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16
Q

What is Selective IgA Deficiency?

A

Transfusion anaphylaxis, mucous membrane infections

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17
Q

What is Hairy Cell Leukemia?

A

Fried egg/sunburst appearance, TRAP +

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18
Q

What is Ataxia Telangectasia?

A

Low Ig A, neuro problems

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19
Q

What is Hyper IgM syndrome?

A

High IgM, low all other Ab

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20
Q

What do T cell deficiency patient die for?

A

Viral infection

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21
Q

What is DiGeorge Syndrome?

A

No thymus/inferior parathyroids, low Ca+2

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22
Q

What is Wiscott-Aldrich?

A

Low IgM, low platelets, high IgA, eczema, petechiae

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23
Q

What does the CD4 count tell you?

A

Status of HIV (normal=1,000)

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24
Q

What does the viral load tell you?

A

Progression of HIV

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25
Q

What is Chronic Mucocutaneous Candidiasis?

A

T cell defect against Candida albicans, chronic fatigue

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26
Q

What is SCID?

A

No thymus, frayed long bones, baby dies by 18mo

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27
Q

What organs have the most CD4 receptors?

A

Blood vessels, brain, testicles, cervix, rectum

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28
Q

What are the 3 tests used to screen for HIV?

A

ELISA: detects IgG Ab to p24 Ag
Western blot: see>2 proteins
PCR: detect virus (use in babies)

29
Q

What is the definition of AIDS?

A

CD4

30
Q

What are the live vaccines?

A

“Bring Your Own Very Small Virus + MMR”

BCG
Yellow Fever
OPV (Sabin)=oral polio
Varicella
Smallpox
RotaVirus
Measles=Rubeola
Mumps
Rubella=German 3 day measles
31
Q

What is !o Biliary Cirrhosis?

A

Anti-mitochondrial Ab, pruritus, females

32
Q

What is 1o Sclerosing Cholangitis?

A

p-ANCA Ab, bile duct inflammation, onion skinning, IBD

33
Q

What is Type I Autoimmune Hepatitis?

A

Anti-SM Ab, young women

34
Q

What is Type II Autoimmune Hepatitis?

A

Anti-LKM Ab, kids

35
Q

What is Bullous pemphigoid?

A

Anti-hemidesmosome Ab, skin bullae

36
Q

What is Celiac sprue?

A

Anti-gliaden ab, eating wheat=> steatprrhea

37
Q

What is CREST syndrome?

A

Anti-centromere Ab

38
Q

What is Dermatitis herpetiformis?

A

Anti-BMZ Ab, Anti-endomysial Ab, vesicles on anterior thigh

39
Q

What is Dermatomyositis?

A

Anti-Jo-1 Ab, myositis +rash

40
Q

What is DM type 1?

A

Anti-islet cell, anti GAD Ab, polyuria, polydipsia, weight loss

41
Q

What is Drug-induced Lupus?

A

Anti-histone Ab, “HIPPPE” causes it

42
Q

What is Gastritis Type A?

A

Anti-parietal cell Ab, atrophic gastritis, adeno CA

43
Q

What is Goodpasture’s?

A

Anti-GBM Ab, attacks lung and kidney, RPGN

44
Q

What is Grave’s disease?

A

Anti-TSHr Ab, hyperthyroid, bug eyes, pretibial myxedema

45
Q

What is Guillain-Barre?

A

Anti-ganglioside Ab, ascending paralysis, 2 weeks after URI

46
Q

What is Hashimotos?

A

Anti microsomal Ab=TPO, hypothyroid

47
Q

What is ITP?

A

Anti platelet Ab, Anti -GP2b3a Ab, thrombocytopenia

48
Q

What is Mixed CT disease?

A

Anti RNP Ab

49
Q

What is Mononucleosis?

A

Heterophile Ab, teenager w/sore throat

50
Q

What is MPGN type II?

A

Anti C3 convertase Ab= C3 nephritic factor

51
Q

What is Multiple Sclerosis?

A

Anti-myelin Ab, middle age female w/vision problems

52
Q

What is Myasthenia Gravis?

A

Anti-AChr Ab, female w/ ptosis, weaker as day goes by

53
Q

What is Paroxysmal hemolysis?

A

Donath Landsteiner Ab, bleeds when cold

54
Q

What is Pemphigus vulgaris?

A

Anti-desmosome Ab, skin sloughs off when touched

55
Q

What is Pernicious anemia?

A

Anti-IF Ab, Vit B12 deficiency=> megaloblastic anemia

56
Q

What is Polyarteritis Nodosa?

A

p-ANCA Ab, attacks gut and kidney, Hep B

57
Q

What is Post-Strep GN?

A

ASO Ab, nephritic w/complement deposition

58
Q

What is Rheumatoid Arthritis?

A

Rheumatoid factor, pain worse in the morning

59
Q

What is Scleroderma?

A

Anti-Scl70= anti-TopoI, fibrosis, tight skin

60
Q

What is Sjogrens?

A

Anti-SSA Ab, dry “sand in” eyes, dry mouth, arthritis

61
Q

What is SLE?

A

Anti-ds DNA/Sm/Cardiolipin, rash, photosensitivity, oral ulcers, RF

62
Q

What is SLE cerebritis?

A

Anti-neuronal Ab, Anti-ribosomal Ab

63
Q

What is Vitiligo?

A

Anti-melanocyte Ab, white patches

64
Q

What is warm hemolysis?

A

Anti-Rh Ab, bleeds at body temperature

65
Q

What is Wegener’s?

A

c-ANCA Ab, attacks ENT, lungs, kidney

66
Q

What is HSP?

A

IgA disease weeks after common cold => Berger’s

67
Q

What is Berger’s?

A

IgA disease 2 weeks after vaccination => Serum sickness

68
Q

What is Alport’s?

A

IgA disease 2 weeks after diarrhea => HSP (Henoch Schonlein Purpura), Polio

PPClues (24 decks)

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