Immunology 1 Flashcards
What is the function of macrophages when the skin is cut?
- Drawn to area of damage
- Phagocytose foreigners
- Secrete chemicals that restrict blood flow from site
- Produce cytokines
- Attracts neutrophils
Why do neutrophils have such a short half life?
They contain strong chemicals that would damage the body if released
What are the non specific humeral factors?
- Growth inhibitors
- Enzyme inhibitors
- Lysins
- Complement proteins
What are the 3 complement pathways?
- Classical
- Alternate
- Lectin
At what point do all three pathways converge?
C5 convertase
Which pathway is a link to the adaptive immune system?
Classical
What happens to the cell when C5 convertase is bound to it?
It is attacked by membrane attack complex
What does membrane attack complex do to the cell?
Generates holes in the membrane
How does the compliment system attract immune cells?
Through chemoattraction
What do somatic cells do when they have been invaded by a pathogen?
- Present antigens of the pathogen on their surface in MHC1 molecules
What happens if a natural killer cell binds to the MHC1
It kills the cell
What is autocrine signalling with reference to cytokine secretion by cells?
The cell signalling to itself
What is paracrine secretion?
The cell signalling to nearby cells
Endocrine secretion?
Signalling to cells far away through the blood
