ANS and NMJ Pharmacology Flashcards
How do nicotinic receptors at ganglia differ from NMJ?
- More readily affected by nicotine
- Some drugs block ACh better at ganglia than NMJ
How can the NMJ be inhibited?
- Blocking re uptake
- Blocking calcium
- Blocking Ca dependent exocytosis
- Blocking post synaptic receptors
NMJ can be promoted by
- Prolonging the AP of the axon by causing Na channels to open for longer.
- Inhibit the effect of acetylcholinesterase with anticholinesterases.
Why are there almost no clinical applications of inhibiting the ganglionic synapse?
Very similar between sympathetic and parasympathetic NS, they cancel each other out.
What receptors exist in the parasympathetic system (post ganglionic)
Metabotropic
What will agonists of the parasympathetic system cause?
- Decrease HR
- Increased enzyme secretion
- Increased salivation
and other parasympathetic functions
Antagonists of the parasympathetic system will
Do the opposite of a parasympathetic response
What is glaucoma?
Inability to drain aqueous humour therefore clouding of vision
How is glaucoma treated?
Agonists of the muscarinic receptors that contract the muscle to ensure the fluid is drained.
How can sympathetic transmission be inhibited?
- Block production of noradrenaline
- Block the transporter that allows noradrenaline to be packaged in a vesicle
- False transmitter that blocks NA binding sites
- Block A and B receptors
What is inhibited in the production pathway of noradrenaline?
DOPA decarboxase
Whats an example of a fake transmitter?
Methyldopa
What else can methyldopa inhibit?
The presynaptic autoreceptors that stimulate the production of NA
How can sympathetic transmission be promoted?
- Increase production of NA
- Inhibit noradrenaline reuptake
What drug can increase the production of NA?
Amphetamine
