Immuno Drugs

Question 1

Diseases you give IL 2 for (increase NK activity)

Answer 1

RCC

Met melanoma

Question 2

Diseases you give G-CSF (filgrastim) + GM-CSF (sargramostim) for

Answer 2

Recovery bone marrow

Question 3

Diseases you give IFN alpha for

Answer 3

Chronic Hep B + C
HHV 8
Melanoma

Question 4

Diseases you give IFN beta for

Answer 4

MS

Question 5

Diseases you give IFNg for

Answer 5

CGD

Question 6

Diseases you give romiplostim, eltrombopag, oprelvekin (IL 11) for

Answer 6

TCP

Question 7

Den-OS-umab

Answer 7

Binds RANK-L
X osteoclast maturation
Osteoporosis

Question 8

Abs vs VEGF - what are they (2), which disease use them for

Answer 8

Use for age macular degen b/c wet bleeding from neovasc causing rapid vision loss

1. RAN-ibizumab
2. BEVA-cizumab - also for CRC + RCC

Question 9

mAb give for paroxysmal nocturnal hemoglobinuria

Answer 9

Eculizumab = vs C5
PNH - patient doesn’t have GPI to anchor protection proteins
No CD55 - C5 doesn’t give a fuck (DAF) - lysis at night when blood pH goes up

Question 10

You give TNFa Abs for many AI disease - name the 4 Abs you could use

Answer 10

Adalimumab
Infliximab
Certolizumab
Etanercept “intercepts” TNFa = decoy receptor

Question 11

2 drugs that affect calcineurin + SEs

Answer 11

Cyclosporine 
1. Nephro > neurotox (but both still risk)
2. Gingival hyperplasia
3. Histuism
Tacrolimus
1. Neuro > nephrotox
2. Diabetes

Question 12

mTOR I + SEs

Answer 12

Sirolimus // ripamycin
Think sirolimus + cyclosporine combo
1. Pan-SIR-topenia
**NOT nephrotox - use for kidney transplant pts

Question 13

IL2 Abs

Answer 13

DAC-lizumab

BAS-iliximab

Question 14

2 drugs that stop purine synthesis for immune suppression

Answer 14

Azothio-purine (= 6MP)
**Watch for combo with allopurinol - ↓XO will ↑6MP - see ↓all bone marrow products
MMF Xs IMP deH