Cytokines to Know

Question 1

Name 5 cytokines secreted by macrophages

Answer 1

IL 1, 6, 8, 12, TNF alpha

Question 2

Which cytokine increases APRs?

Answer 2

IL 6

Question 3

2 cytokines secreted by ALL T cells

Answer 3

IL 2 + 3

Question 4

What cytokine do Th1 cell secrete? 4 fxns

Answer 4

IFNg

1. Activates NK cells
2. Increases MHC expression + antigen presentation by all cells (show me what you’ve got!!!)
3. Activates macrophages
4. Blocks Th2 conversion

Question 5

3 cytokines secreted by Th2 cells?

Answer 5

IL 4, 5, 10

Question 6

IL 1

Answer 6

= osteoclast activating gactor
FEVER b/c increase PGE2 at hypothalamus
Activates endo to express adhesion molecules
Recruit WBC

Question 7

IL 8

Answer 7

Neutrophil chemotaxis to clear infections

“clean up on aisle 8”

Question 8

IL 12

Answer 8

Th1 differentiation

NK activation

Question 9

TNF alpha

Answer 9

Septic shock
Endo activation, vasc leak, WBC recruit
Is what causes WEIGHT LOSS in cancer

Question 10

IL 2

Answer 10

Stim

1. Helper + cytotox T cells
2. Reg T cells
3. NK cells

Question 11

IL 3

Answer 11

Bone marrow stem cell differentiation

Question 12

IL4

Answer 12

Th2 differentiation

Switch to IgE (and IgG)

Question 13

IL 5

Answer 13

IgA switch

Eosinophils

Question 14

IL 10

Answer 14

atTENuate the immune response (along w/ TGF beta)

Question 15

Hot
Tbone
stEAK

Answer 15

IL 1 - hot (fever)
2 - stim T cells
3 - bone marrow prod
4 - IgE
5 - IgA (5 am = red sunrise = eosinophils) 
6 - IgG + aKute phase reactant

Question 16

Difference in fxn between IFN a/b and IFN g

Answer 16

IFNa/b - made and released by virally infected cells so that local neighbors enter non-infectious state by degrading viral nucleic acids + protein
IFNg activates macro, Th1, NK (also anti-tumor by making tumors increase MHC 1 expression
“Alpha activates, B be less”

Question 17

Which cytokine maintains granulomas

Answer 17

Think TB
Infected macrophage secretes IL 12 -> activated T/NK cells -> secrete IFNg -> binds Janus kinases 1+2 -> STAT1 TF -> activate genes for M.TB killing
Defective IFNg R -> disseminated TB disease