Cytokines to Know Flashcards
Name 5 cytokines secreted by macrophages
IL 1, 6, 8, 12, TNF alpha
Which cytokine increases APRs?
IL 6
2 cytokines secreted by ALL T cells
IL 2 + 3
What cytokine do Th1 cell secrete? 4 fxns
IFNg
- Activates NK cells
- Increases MHC expression + antigen presentation by all cells (show me what you’ve got!!!)
- Activates macrophages
- Blocks Th2 conversion
3 cytokines secreted by Th2 cells?
IL 4, 5, 10
IL 1
= osteoclast activating gactor
FEVER b/c increase PGE2 at hypothalamus
Activates endo to express adhesion molecules
Recruit WBC
IL 8
Neutrophil chemotaxis to clear infections
“clean up on aisle 8”
IL 12
Th1 differentiation
NK activation
TNF alpha
Septic shock
Endo activation, vasc leak, WBC recruit
Is what causes WEIGHT LOSS in cancer
IL 2
Stim
- Helper + cytotox T cells
- Reg T cells
- NK cells
IL 3
Bone marrow stem cell differentiation
IL4
Th2 differentiation
Switch to IgE (and IgG)
IL 5
IgA switch
Eosinophils
IL 10
atTENuate the immune response (along w/ TGF beta)
Hot
Tbone
stEAK
IL 1 - hot (fever) 2 - stim T cells 3 - bone marrow prod 4 - IgE 5 - IgA (5 am = red sunrise = eosinophils) 6 - IgG + aKute phase reactant
Difference in fxn between IFN a/b and IFN g
IFNa/b - made and released by virally infected cells so that local neighbors enter non-infectious state by degrading viral nucleic acids + protein
IFNg activates macro, Th1, NK (also anti-tumor by making tumors increase MHC 1 expression
“Alpha activates, B be less”
Which cytokine maintains granulomas
Think TB
Infected macrophage secretes IL 12 -> activated T/NK cells -> secrete IFNg -> binds Janus kinases 1+2 -> STAT1 TF -> activate genes for M.TB killing
Defective IFNg R -> disseminated TB disease
