CHAPTER: GI (Embryo, Anatomy, Phys) Flashcards

1
Q

Structures in the hepatoduodenal lig

A
Portal triad 
1. Hepatic art (going)
2. Portal vein (going)
3. Common bile duct (coming)
Pringle = clamp all 3 to buy time to find liver bleeder
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2
Q

Structures contain in the gastrocolic // splenorenal ligaments

A

Gastrocolic = greater curve stomach to transverse colon
Contains L + R gastro-epiploic arteries
Spleno-renal ligament connects spleen to post ab wall
1. Splenic A + V
2. Tail of pancreas (aka what isn’t retro)

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3
Q

What are 2 ways you can get into the lesser sac?

A

Lesser sac (post) and the greater sac (ant) are created by the ligaments
On L: gastrosplenic
On R: gastrohepatic
1. Cut through the gastrohepatic to get in
2. Foramen of Winslow = natural opening between liver, hepatoduo lig, and duodenum

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4
Q

Name the 4 layers of the gut wall in order and the structures within them

A
MSMS
Mucosa 1. epi 2. LP (CT) 3. muscularis mucosa 
*Erosions only through mucosa*
Submucosa w/ Meissners to secrete fluids
*Ulcers extend into subM*
Muscularis externa - inner circ, Myenteric for motility, outer long
4th: 
1. Intraperitoneal organs = serosa
2. Retro = adventitia
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5
Q

Fastest section of the GI tract

A

Duodenum > ileum > stomach

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6
Q

Histo for duodenum + what absorbed here

A

IRON
Villi + MV
Brunner - make bicarb
Crypts of L = regen

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7
Q

Histo jejunum + what absorbed here

A

FAT + FOLATE
Plicae circulares ↑↑SA
Lacteals
Crypts of L

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8
Q

Histo ileum + what absorbed here

A

B12, IF, BILE ACIDS
Peyers patches
↑est # goblet cells
Crypts L, plicae

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9
Q

Difference in histo between stomach and colon

A

Both simple columnar
Stomach: gastric pits (acid) + glands (mucous)
Colon: crypts of goblet cells only

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10
Q

Only BV off aorta that runs in front of the IVC

A

Gonadal

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11
Q

What are connects the sup + inf mesenteric arteries

A

Marginal artery
@ L flexure
If you have to ligate IMA, this is how the colon with get colateral from SMA

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12
Q

What condition would cause the SMA to compress the duodenum between it and the aorta causing post prandial pain?

A

Malnutrition -> lose fat around the SMA

Duodenum between SMA (top) and aorta (bottom)

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13
Q

BS, sympa, and para to foregut, midgut, and hindgut

A

Fore: celiac
Mid: SMA
Both sympa = greater + lesser splanchnic n; para = vagus
Hind: IMA. lumbar splanchnic, pelvic n (para)

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14
Q

Trace the common hepatic artery’s branches as it comes out of SMA

A

Proper hepatic
1. Into liver via hepato-duo lig (portal triad)
2. R gastric art (lesser curve)
Gastroduo art
1. R gastroepip (greater curve, L coming from splenic)
2. Ant pancreaticoduodenal
3. Post-sup pancreaticoduodenal

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15
Q

What are the 3 veins that varices are trying to get access to for shunting

A

GOAL = direct drain into IVC
Esophagus - back up into L gastric so get into azygos
Caput medusae - open paraumbilical veins into small epigastric veins
Anorectal varices - back up into sup rectal to get into middle inf rectal

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16
Q

A/LN/V and cancer above the pectinate line

A

A: sup rectal (IMA)
V: sup rectal -> IMV -> portal
LN: int iliac
Adenocarcinoma (GI tract)

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17
Q

A/N/V/LN and cancer below the pectinate line

A

A: inf rectal (int pudendal) - ↓BS post causes anal fissure
V: inf rectal -> internal iliac -> IVC (↑bioavail for drugs)
LN: superficial inguinal
N: pudendal nerve = somatic innervation = painful hemroid
SCC (HPV)

18
Q

What do Ito cells? What organ?

A

Liver
Store vit A
Produce ECM

19
Q

Which zone liver affected by metabolic toxins

A

3

This is where p450 is - activates the drugs therefore ↑est risk damage

20
Q

Zone for alcoholic vs viral hepatitis

A

1 - viral

3 - alcoholic (p450)

21
Q

Zone for yellow fever

A
2
Yellow fever = flavi (+ssRNA) 
Back pain
Jaundice
Bloody stool 
Aedes mosquito, live atten vaccine
22
Q

Role of Kupffer

A

Liver macrophages

Breakdown RBCs to make BR

23
Q

Structures in the femoral triangle vs sheath

A

NAVL
Triangle = N, A, V
Sheath = A, V, deep inguinal LN in femoral canal
Go medial for central venous access

24
Q

What is the double duct sign

A

Stone obstructs ampulla vater

See the main and accessory pancreatic ducts dialted

25
3 parts Hesselbach triangle
Rectus ab Inf epigastric vessels Inguinal ligament Why direct hernias are medial to inf epi vessels (vs indirect lateral)
26
What hernia gives you Hourglass stomach Fundus stomach into thorax Entire stomach into thorax
Sliding hiatal Paraesophageal Hiatal
27
Where are K cells - what do they excrete?
D +J GIP = incretin ↑insulin release ↓gastric acid (stop digesting, we've got it down here) INCRETIN EFFECT is why you get so much more insulin with PO > IV glucose loads
28
Symptoms of a VIPoma
VIP stim parasympa (M3) @ sphincters, GB, SI - rest, digest (also how macrolides stim GI motility) Watery diarrhea HypoK Achlorhydria
29
Fxn secretin
↑bicarb from pancreas to make SI more basic for enzymes to work
30
Where does CCK vs secretin work in the pancreas?
CCK @ acinar cells - ↑secretions | Secretin @ ductal cells - ↑bicarb
31
Enzyme for protein digestion
Pepsin from chief cells in stomach | Acid in stomach activates - therefore protein digestion starts in stomach
32
2 ways vagus ↑acid secretion
ACh @ parietal cells GRP = gastrin releasing peptide @ G cells (duo) -> gastrin into circulation to bind parietal and #1 ECL cells (release H)
33
3 phases of acid secretion
1. Cephalic = small, thought, taste - vagus 2. Gastric = stomach distension - gastrin 3. Intestinal ↓acid via YY peptide from ECL cells
34
SI BB enzymes that activate trypsin
Enterokinase | Enteropeptidase
35
What 2 AAs do bile acids get conj to making them H2O sol?
Glycine or taurine
36
What enzyme is the rate lim step of bile acid synthesis
Cholesterol 7alpha hydrox
37
2 SI receptors that absorb monosacc
SGLT1 - glucose + galactose Na co-trans (use the Na gradient) GLUT 5 - facilitated diffusion fructose
38
Enzyme that converts UCBR into CBR in the liver to make H2O sol
UDP glucuronosyl transferase Gut bacteria convert CBR -> urobili Stercobilin - feces Urobilin - urine
39
Which fold failures cause omphalocele + gastroschisis vs bladder exstrophy
O/G - lateral fold closure defect | Bladder out - caudal fold closure defect
40
Cause jejunal and ileal atresia
Disrupt mesenteric vessels -> ischemic necrosis Triple bubble or apple peel Vs duodenal atresia = fail recanalize Double bubble
41
Exposure to macrolide ↑risk what
Hypertrophic pyloric stenosis 1st born males too Olive mass 2-6 wks after bith PROJECTILE vomiting
42
Fore vs mid vs hind gut derivatives
Fore - mouth -> duodenum (celiac art) Mid - duodenum -> prox 2/3 transverse (SMA) Herniates through umbilical ring to grow Hind - to above the pectinate (IMA)