Immunity II

Question 1

Lack of response to antigens that is induced by exposure of lymphocytes to these antigens:

Answer 1

Immunologic tolerance

Question 2

The ability to discriminate between self and non-self antigens:

Answer 2

immunologic tolerance

Question 3

If immunologic tolerance failures:

Answer 3

Autoimmunity

Question 4

Normally, microbes are _____ and self-antigens are ____

Answer 4

immunogenic; tolerogenic

Question 5

Developing lymphocytes encounter self antigens in central lymphoid organs:

Answer 5

Central tolerane

Question 6

Nature lymphocytes encounter self antigens in peripheral tissues:

Answer 6

Peripheral tolerance

Question 7

In central T cell tolerance, what are the two outcomes of self reactive T cells?

Answer 7

1. negative selection or deletion
2. development of regulatory T cells

Question 8

In peripheral T cell tolerance ____ block the activation of self-reactive lymphocytes

Answer 8

regulatory T cells

Question 9

In peripheral T cell tolerance, ____ is the functional inactivation of T cells (lack of costimulation)

Answer 9

anergy

Question 10

In peripheral T cell tolerance, ___ involves apoptosis of self-reactive lymphocytes

Answer 10

deletion