Granulation tissue vs. Granulomatous tissue

Question 1

Describe granulation tissues:

Answer 1

It is highly vascular, and when viewed with the naked eye is red and granular

Question 1

Is the tissue that repairs wounds:

Answer 1

granulation tissue

Question 2

In granulation tissue, what serves as the scaffolding for endothelial cells and fibroblasts that grow into the clot from the wound margin?

Answer 2

fibrin strands

Question 3

In granulation tissues the wound fills with a blood clot and the fibrin strands in the clot serve as scaffolding for _____ and ____ that grow into the clot from the wound margin

Answer 3

endothelial cells and fibroblasts

Question 4

In granulation tissue, endothelium forms new ______ and fibroblasts makes new _____ that restores _____

Answer 4

vascular channels; collagen; tensile strength

Question 5

What are the two main cell types in granulation tissue?

Answer 5

1. endothelial cells
2. fibroblasts

Question 6

What is the terminal event in an injury/inflammatory lesion?

Answer 6

repair

Question 7

What would happen to wounds without granulation tissue?

Answer 7

Wounds would not heal

Question 8

Granulation tissue may overgrow and form an unwelcome mass called a:

Answer 8

pyogenic granuloma

Question 9

A pyogenic granuloma can simply be considered:

Answer 9

Too much of a good thing (granulation tissue)

Question 10

An abscessed tooth left untreated may develop a mass of chronically inflamed granulation tissue at the root tip called a:

Answer 10

periapical dental granuloma

Question 11

This is a photo of _______.
What do the red areas represent?

Answer 11

Granulation tissue; newly formed vascular channels

Question 12

This image shows a _____. Which is an overgrowth of inflamed ______.

Answer 12

Pyogenic granuloma; inflamed granulation tissue

Question 13

A persistent growth of inflamed granulation tissue at the apex of a tooth with a necrotic pulp:

Answer 13

periapical dental granuloma

Question 14

Tissue that contains granulomas:

Answer 14

granulomatous tissue

Question 15

a collection of macrophages, a few lymphocytes, and a surrounding thin collar of fibroblasts:

Answer 15

granuloma

Question 16

macrophages in a granuloma may also be called:

Answer 16

epithelioid histiocytes

Question 17

Granulomas may or may not have:

Answer 17

multinucleated giant cells

Question 18

In granulomatous tissue, if nuclei are arranged in a radial pattern (horseshoe or necklace) it is a:

Answer 18

Langhans giant cell

Question 19

In granulomatous tissue, if nuclei are randomly arranged in the cytoplasm this is a:

Answer 19

Foreign body type giant cell

Question 20

most injuries and infections provoke ______, a vascular response that displays the cardinal signs of inflammation (rubor, calor, dolor, tumor)

Answer 20

exudative inflammation

Question 21

A limited group of noxious agents (microbes & foreign material) do not provoke _____, but instead they cause the formation of ____

Answer 21

exudative inflammation; granulomas

Question 22

A limited group of noxious agents (microbes & foreign material) do not provoke exudative inflammation, but instead they cause the formation of granulomas. This response is known as:

Answer 22

Granulomatous inflammation

Question 23

Lacking redness, swelling, and pain ________ are always chronic and may be silent for weeks to months before symptoms arise

Answer 23

granulomatous diseases

Question 24

______ is the mother of all infectious granulomatous diseases; ____ is another example

Answer 24

Tuberculosis; leprosy

Question 25

In tuberculosis, the granulomas characteristically exhibits a pattern of necrosis referred to as _____, therefore the term _____

Answer 25

caseous (cheese-like) necrosis; caseating granulomas

Question 26

What can be seen in this high-power image? How do you know?

Answer 26

Langhans giant cell; radial (horsehoe) arrangement of nuclei

Question 27

What can be seen in this medium-power image? How do you know?

Answer 27

Several foreign body giant cells; random arrangement of nuclei in cytoplasm

Question 28

A focal collection of epithelia histiocytes with a sprinkling of lymphocytes, maybe one or more multinucleated giant cells and a thin collar of fibroblasts surrounding them all:

Answer 28

Granuloma