Immune Tolerance Flashcards
Consequences of excessive immune system?
Allergies. Autoimmune disease.
Consequences of deficient immune system?
Infection. Cancer.
Major allergy immune system cell?
Mast cell.
What causes acute anaphylactic shock?
IgE and Mast cells.
What causes delayed type hypersensitivity?
T cells.
2 types of allergy?
Acute anaphylactic shock. Delayed type hypersensitivity.
Types of failure of immune regulation?
Autoimmunity. Allergy. Hypercytokinemia and sepsis.
What is Hypercytokinemia and sepsis?
Too much immune response.
What do you call a t cell after it has binded to mhc complex on antigen presenting cell?
Effector.
What converts a naive t cell to an effector t cell?
Antigen recognition. Co-stimulation. Cytokine release.
What occurs as the pathogen is eliminated?
Apoptosis of lymphocytes that lose their survival signals (antigen). Formation of memory cells.
What cells are involved in resolution and repair after infection is cleared?
Macrophages and fibroblasts.
What are the two types of tolerance in immunity?
Central and peripheral tolerance.
When does central tolerance occur?
Before immune cell enters bloodstream.
When does peripheral tolerance occur?
Once immune cell is in bloodstream.
What is central tolerance?
Lymphocytes that recognise self antigens are deleted (apoptosis) or made harmless before they enter bloodstream.
What is peripheral tolerance?
Destroy or control any self reactive T or B cells which do enter the circulation.