Cholestrol Flashcards
Where is fat derived from?
Diet, De novo biosynthesis, Storage depots in adipose.
What enzyme breaks down dietary fat?
Lipases
What do bile salts do?
They emulsify fats in the intestine.
Why are bile salts needed?
The aid digestion and absorption of fats and fat soluble vitamins.
Where are bile salts generated and stored?
Generated in liver and stored in gallbladder.
What is steatorrhea?
Fatty stool caused by undigested fat and unabsorbed fat.
What can cause steatorrhea?
Lack of bile salts.
What is orlistat?
A drug that inhibits gastric and pancreatic lipases.
What is orlistat used to treat?
Obesity.
Side effects of orlistat?
Steatorrhea, abdominal pain, urgency to defecate.
Why are lipids transported as lipoproteins?
Lipids are hydrophobic and so to transport in aqeuous plasma they have to be transported within proteins.
VLDL role?
Endogenous fat transport
HDL role
Reverse cholesterol transport
What type of cell absorbs products of digestion?
Enterocytes
Chylomicron pathway?
Triglycerides incorporated in chylomicron. Transported via lymphatics. Enters bloodstream. Acquires apoproteins from HDL.
What allows chylomicrons to be detected in the blood stream?
Apoproteins
How are contents of chylomicron accessed?
Lipoprotein lipase binds to apoprotein and breaks down chylomicron to take in contents.