Complex disease and pharmacogenetics

Question 1

Limitations of genome wide association studies?

Answer 1

Can’t identify causal variants. Threshold for amount of genome you can check. Environmental influence (epigenetic).

Question 2

Benefits of genome wide association studies?

Answer 2

Identify at risk individuals.

Question 3

What is a mendelian trait?

Answer 3

Trait controlled by single gene.

Question 4

What is a complex Trait?

Answer 4

Controlled by multiple genes + the effect of environment.

Question 5

How can heritability be studied?

Answer 5

Comparing trait between two identical twins. Comparing trait between two non identical twins. If trait is presented similar between identical twins and not similar between non identical then it is a heritable trait.

Question 6

What is another name for identical twins?

Answer 6

Monozygotic twins.

Question 7

Another name for non identical twins?

Answer 7

Dizygotic twins

Question 8

What is pharmacogenomics?

Answer 8

The study of variability in drug response due to genetic differences.