IMMUNE SYSTEM Flashcards
body defence mechanism is
WBC include granulocyte, lymphocyte, leukocyte, monocyte
b cell will matured and become
plasma cells
pluripotent stem cell have
myeloid lineage lymphoid lineage
myeloid lineage have 3types
granulocyte precusor -neutrophil, baso
monoblast -macrophage
dendritic cells
lymphoid lineage have 2 types
lymphocytes - T&B cells
NK killer cells
neutrophiles granule appearance
none 90-95%
polymorphonucleur cell inflammatory reapose are
neutrophils
monocyte 5-10% short live and will enter extravascular pool become
macrophages as resident in tissue
dendritic cells hv many cytoplamic process as antigen presenting cell found in
peripheral blood, lymph nodes, bone marrow, tissu
lymphoid lineage have high T lymphocyte in
blood circulation
site of production of B lymphocytes (plasma cells0
bone marrow,
spleen (50-60%)
t lymphocytes mature in
thymus
plasma cells or matured b cell produce
antibody
2types of T lymphocytes are
CD4/ helper T cells -regulate other immune cells/antibody
CD8/ cytotoxic T lymphocytes- kill infected cells
natural killer dont need thymus to mature l fx
kill and lyse virus infected cells and tumor cells
lymphocyte recircultion occurs between the blood tissue and lymphoid organs it is regulated by
immune surveleillance control according to cell types
pathway of lymphocytes
blood-organ-cells-lymph node-lymphatic system- thoraxic duct- heart-bood circulation
factors of development of lymphoytes
microenvironment
secondary lymphoid organs (lymph node, spleen) major fx
residence for variety of lymphoid cells
traps for antigen
anatomical site which immune response initiated
primary lymphoid organ are
t cells -thymus
b cells -bone marrow
immune response occur in
lymph nodes
2 components of immune system are
innate or non specific
adaptive/acquired specific
innate or non specific are rapid have 2types
humoral
cellular - acute phase reactant macrophages,neutophils, dendritic, Nk cells
2types of adaptive/acquired or specific , slower response bcs cell need to recognize pathogen
humoral - antibody B cells
celullar - lymphocytes T cell
adaptive T cell immunity is
cell mediated immunity
adaptive B cell immunity is
antibody mediated immunity
adaptive immune system(T&B lymphocytes) of b cell have
memory cell
plasma cell
fx of immune system
protect human body from foreign invaders
4main components of immune response
pathogen recognition -by innate immune system release cytokine and phagocytosis occur
acute inflammatoty response -prevent infection from spread
antigen presenting in adaptive immune system - specific T helper cells
DC4 helper T cells response adaptive immune system antibody/cytotoxic T cell
abnormalities of immune response
immunodeficiency (HIV)
hypersensitivity (asthma)
autoimmune (SLE)
malignancy
