IMMUNE SYSTEM Flashcards

1
Q

body defence mechanism is

A

WBC include granulocyte, lymphocyte, leukocyte, monocyte

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2
Q

b cell will matured and become

A

plasma cells

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3
Q

pluripotent stem cell have

A

myeloid lineage lymphoid lineage

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4
Q

myeloid lineage have 3types

A

granulocyte precusor -neutrophil, baso
monoblast -macrophage
dendritic cells

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5
Q

lymphoid lineage have 2 types

A

lymphocytes - T&B cells

NK killer cells

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6
Q

neutrophiles granule appearance

A

none 90-95%

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7
Q

polymorphonucleur cell inflammatory reapose are

A

neutrophils

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8
Q

monocyte 5-10% short live and will enter extravascular pool become

A

macrophages as resident in tissue

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9
Q

dendritic cells hv many cytoplamic process as antigen presenting cell found in

A

peripheral blood, lymph nodes, bone marrow, tissu

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10
Q

lymphoid lineage have high T lymphocyte in

A

blood circulation

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11
Q

site of production of B lymphocytes (plasma cells0

A

bone marrow,

spleen (50-60%)

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12
Q

t lymphocytes mature in

A

thymus

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13
Q

plasma cells or matured b cell produce

A

antibody

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14
Q

2types of T lymphocytes are

A

CD4/ helper T cells -regulate other immune cells/antibody

CD8/ cytotoxic T lymphocytes- kill infected cells

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15
Q

natural killer dont need thymus to mature l fx

A

kill and lyse virus infected cells and tumor cells

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16
Q

lymphocyte recircultion occurs between the blood tissue and lymphoid organs it is regulated by

A

immune surveleillance control according to cell types

17
Q

pathway of lymphocytes

A

blood-organ-cells-lymph node-lymphatic system- thoraxic duct- heart-bood circulation

18
Q

factors of development of lymphoytes

A

microenvironment

19
Q

secondary lymphoid organs (lymph node, spleen) major fx

A

residence for variety of lymphoid cells
traps for antigen
anatomical site which immune response initiated

20
Q

primary lymphoid organ are

A

t cells -thymus

b cells -bone marrow

21
Q

immune response occur in

A

lymph nodes

22
Q

2 components of immune system are

A

innate or non specific

adaptive/acquired specific

23
Q

innate or non specific are rapid have 2types

A

humoral

cellular - acute phase reactant macrophages,neutophils, dendritic, Nk cells

24
Q

2types of adaptive/acquired or specific , slower response bcs cell need to recognize pathogen

A

humoral - antibody B cells

celullar - lymphocytes T cell

25
Q

adaptive T cell immunity is

A

cell mediated immunity

26
Q

adaptive B cell immunity is

A

antibody mediated immunity

27
Q

adaptive immune system(T&B lymphocytes) of b cell have

A

memory cell

plasma cell

28
Q

fx of immune system

A

protect human body from foreign invaders

29
Q

4main components of immune response

A

pathogen recognition -by innate immune system release cytokine and phagocytosis occur
acute inflammatoty response -prevent infection from spread
antigen presenting in adaptive immune system - specific T helper cells
DC4 helper T cells response adaptive immune system antibody/cytotoxic T cell

30
Q

abnormalities of immune response

A

immunodeficiency (HIV)
hypersensitivity (asthma)
autoimmune (SLE)
malignancy