HAEMOPOIESIS

Question 1

what is haemopoiesis

Answer 1

formation of blood cells

Question 2

fetus 2-7months will start haemopoiesis in

Answer 2

spleen, liver

Question 3

measoblastic haemopoiesis is in

Answer 3

yolk sac 3-4eerk primitive blast

Question 4

stem cell is

Answer 4

asymetrical dividing, multiple types of cell

Question 5

totipotent - form all cell types, embryonic placental cells , zygote
pluripotent - give rise to all cell that make up body
multipotent- develop >1 cell line but limited , lymphoid myeloid stem cell
another types is

Answer 5

progenitor cells

Question 6

erythoid megakaryote blast types

Answer 6

cfu eythroid system erythroblast > mature rbc

Question 7

granulocyte presucor

Answer 7

cfu > neutrophils

cfu > monocyte >permenant resident in tissue > macrophages

Question 8

eosinophils - red granule

basophils - IgE on surface fx as

Answer 8

hypersensitivity

inflammatory

Question 9

eosinophil is bilobed nucleus and fx as

Answer 9

allergic reaction w parasitic infestations

Question 10

basophil is ___ nucleus

Answer 10

multi lobed

Question 11

b lymphocyte react to

Answer 11

antigenic stimulation produce immunoglobulin

Question 12

Homeotopoitic growth factoors is glycoproteins and act as

Answer 12

hormone regulate proliferatior differentiation of hemopoietic progenitor cells

Question 13

primary lymphoid organs

Answer 13

bone marrow

thymus

Question 14

secondary lymphoid organs

Answer 14

spleen

liver

Question 15

extramedullary haemopoisis fx is

Answer 15

produce fxly mature antigen presenting cells and phagocytes

Question 16

malignant disease myelofibrosis cause

Answer 16

bone marrow unsuitable to support production cause hepatomegaly

Question 17

b naive cell is from

Answer 17

clonal expansion of somatic hypermutation

Question 18

b&t cell switch to

Answer 18

plasma cells&memory b cells

Question 19

inner medula of thymus is known as

Answer 19

hassall’s corpuscle

Question 20

child thymus have medula that connected to cortex while adult _____

Answer 20

become fibroblast tissue and adult thymus

Question 21

t cells from bone marrow enter thymus cortex undergo matruration nd MHC induced - to + selection enter back to plasma become

Answer 21

CD4 + CD 8+

Question 22

CD+ capable to recognize MHC to keep i it alive

CD- is

Answer 22

eliminates of T cells that react too strong with self MHC