HAEMOPOIESIS Flashcards
what is haemopoiesis
formation of blood cells
fetus 2-7months will start haemopoiesis in
spleen, liver
measoblastic haemopoiesis is in
yolk sac 3-4eerk primitive blast
stem cell is
asymetrical dividing, multiple types of cell
totipotent - form all cell types, embryonic placental cells , zygote
pluripotent - give rise to all cell that make up body
multipotent- develop >1 cell line but limited , lymphoid myeloid stem cell
another types is
progenitor cells
erythoid megakaryote blast types
cfu eythroid system erythroblast > mature rbc
granulocyte presucor
cfu > neutrophils
cfu > monocyte >permenant resident in tissue > macrophages
eosinophils - red granule
basophils - IgE on surface fx as
hypersensitivity
inflammatory
eosinophil is bilobed nucleus and fx as
allergic reaction w parasitic infestations
basophil is ___ nucleus
multi lobed
b lymphocyte react to
antigenic stimulation produce immunoglobulin
Homeotopoitic growth factoors is glycoproteins and act as
hormone regulate proliferatior differentiation of hemopoietic progenitor cells
primary lymphoid organs
bone marrow
thymus
secondary lymphoid organs
spleen
liver
extramedullary haemopoisis fx is
produce fxly mature antigen presenting cells and phagocytes
malignant disease myelofibrosis cause
bone marrow unsuitable to support production cause hepatomegaly
b naive cell is from
clonal expansion of somatic hypermutation
b&t cell switch to
plasma cells&memory b cells
inner medula of thymus is known as
hassall’s corpuscle
child thymus have medula that connected to cortex while adult _____
become fibroblast tissue and adult thymus
t cells from bone marrow enter thymus cortex undergo matruration nd MHC induced - to + selection enter back to plasma become
CD4 + CD 8+
CD+ capable to recognize MHC to keep i it alive
CD- is
eliminates of T cells that react too strong with self MHC
