Immune System Flashcards
Proteins produced by B cells in response to the presence of an antigen of a foreign molecule
Antibodies “immunoglobulins”
Biggest of all, can’t cross membranes, first released
IgM
Present in salvia, mucus, and tears. Keeps pathogens from entering blood
IgA
Assist B cells in recognizing pathogens
IgD
Most common, smallest, can cross placenta
IgG
Binds with allergens, cause release of histamine
IgE
Antibodies bind to the pathogens and neutralize them
Neutralization
The process of coating a pathogen with antibodies
Opsonization
Your immune system attacks healthy cells by mistake
Autoimmunity (autoimmune disease)
Inherited genetic mutations. Over 150 different kinds. Lack of functioning B cells
PIDD (primary immune deficiency disease)
A severe loss of function of the entire immune system. Caused by a retrovirus (HIV) which destroys helper T cells
Acquired immunodeficiency disease
An inaccurate immune system response to something usually harmless like pollen, fur, a particular food or dust. Body releases histamine causing inflammation and construction of smooth muscle
Allergies/asthma
Forms mechanical barrier that prevents entry of pathogens and other harmful substances
Intact skin epidermis
Skin secretions (perspiration and sebum) make epidermal surface acidic, which inhibits bacterial growth; sebum also contains bacterial chemicals
Acid mantle
Provides resistance against acids, alkalis and bacterial enzymes
Keratin
Form mechanical barrier that prevents entry of pathogens
Intact mucous membranes
Traps microorganisms in respiratory and nasal passages
Mucus
Filter and trap microorganisms in nasal passages
Nasal hairs
Propel debris- laden mucus away from lower respiratory passages
Cilia
Contains concentrated hydrochloric acid and protein digesting enzymes that destroy pathogens in stomach
Gastric juice
Inhibits growth of most bacteria and fungi in female reproductive tract
Acid mantle of vagina
Continuously lubricate and cleanse eyes and oral cavity; contain lysozyme, an enzyme that destroys microorganisms
Lacrimal secretion (tears) and saliva
Normally acid PH inhibits bacteria growth; cleanses the lower urinary tract as it flushes from the body
Urine
Systemic response initiated by pyrogens; high body temp inhibits microbial multiplication and enhances body repair process
Fever
Proteins released by virus infected cells and
certain lymphocytes that protect uninfected tissue cells from viral takeover; mobilize immune system
Antimicrobial proteins interferons
Granules of basophils and most cells; released in response to mechanical injury, presence of certain microorganisms and chemicals released by neutrophils
Histamine source
Promotes vasodilation of local arterioles; increases permeability of local capillaries, promoting exudare formation
Histamine effect
A plasma protein, kininogen, is cleaved by the enzyme kallikrein found in plasma, urine, salvia and in lysosomes of neutrophils and other types of cells; cleavage releases active kinin peptides
Kinins source
Same as for histamine; also induce chemotaxis of leukocytes and prompt neutrophils to release lysosomal enzymes, thereby enhancing generation of more kinins; induce pain
Kinins effect
Inflammatory chemicals
Histamine
Kinins
Protein containing fluid transported by lymphatic vessels
Lymph
Called lymph and return to veins uses peristalsis, one way valves, and muscle contraction to circulate lymph
Lymphatic vessels
Filters the lymph and removes impurities such as carbon, cancer cells, pathogens and dead
Lymph nodes
Filters blood for the lymphatic system and stores lymphocytes and macrophages to kill pathogens in blood, removes old red blood cells
Spleen
Produces lymph
Liver
Swollen spleen due to infection
Splenomegaly
Swollen tonsils due to draining bacterial infection in pharynx
Tonsillitis
Blockage, radiation scarring, or cancerous lymph vessels/nodes that cause tissue swelling
Lymphedema
Tropical parasitic worms invade they lymph nodes and block them
Filariasis (elephantiasis)
Cancer of the lymphatic system)
Lymphoma
Immune system function
Recognize foreign molecules and act to immobilize, neutralize, or destroy them
Any harmful or disease causing organism
Pathogen
5 types of pathogens (largest to smallest)
Parasitic worm Fungi Protozoa Bacteria Virus
2 types of defense
Innate
Adaptive
2 types of adaptive defense
Cell mediated immunity
Antibody mediated immunity
Uses white blood cells to attack pathogens
Cell mediated immunity
Produced in thymus
T cells
Major type of lymphocyte used in cell mediated immunity
T cell
3 types of cells
Helper T
Killer T
Suppressor T
Most important type of cell because it coordinates entire adaptive response. It also assists the killer t in identifying pathogens
Helper t
(Cytotoxic) attacks and kills pathogens
Killer T
Switched off the immune response
Suppressor T
Produced in blood plasma
B cells
What do B cells do?
Produce antibodies which tag pathogens for destruction
Creates memory to make immune response more powerful
Produced antibodies in the fluids humors of the body (blood, phlegm, and bile)
Antibody mediated immunity
Markers on foreign molecules invoking an adaptive immune response
Antigens
Markets that identify the cell as “self” preventing an adaptive immune response
Self antigens
Specific system with memory that is directed against particular pathogens
Adaptive immune system
1st line of defense
Surface barriers (skin) Digestive system (stomach acid & saliva) Respiratory system (mucus)
2nd line of defense (internal)
Phagocytes
Basophils
Inflammation response
Fever response
Engulfs/destroys pathogen at site of infection
Phagocyte
Engulfs cellular debris, foreign substances, bacteria and cancer cells
Macrophages
Most abundant, engulfs bacteria, they die in process too
Neutrophils
Defends against parasitic worms by discharging granules on prey
Eosinophils
Three types of phagocytes
Macrophages
Neutrophils
Eosinophils
Releases histamine in response to allergic reaction
Basophils
Actively scan the body for cells for “self antigens” no ID badge cells are attacked
NK cells
This is the body’s 1st line of defense against cancer
NK cells
Most cells release histamine which causes redness and heat
Vasodilation
Inflammation response
Vasodilation
Vascular permeability
Phagocytes arrive
Swelling
Vascular permeability
The body’s specific defenses against invading pathogens include
Killer T cells
Another one of the body’s specific defenses against invading pathogens is
Antibodies
Allowing vascular permeability is a response associated with
Inflammation
The process of coating a pathogen with antibodies is called
Opsonization
The body’s nonspecific defenses against pathogens include
Fevers
This type of defense cell is the first line of defense vs cancer cells as they check cells for antigens to make sure they belong
Natural killers
An immune response is triggered by an
Antigen
The inflammatory response can cause
Pain, swelling and fever
The body’s other nonspecific defense against invading pathogens includes
Mucus, sweat and tears
This type of lymphocyte creates memory to make the immune response more powerful
B cells
Unlike passive immunity, in active immunity antibodies are produced by
B cells
What cells are involved in nonspecific immunity
Neutrophils
This cell coordinates the entire adaptive response
Helper T
Proteins produced by B cells in response to the presence of antigen of a foreign molecule are called
Immunoglobulin