ILA: MOLECULAR MEDICINE

Question 1

A promoter sequence is coded in:

Answer 1

Single-stranded DNA

Question 2

A gene sequence is coded in:

Answer 2

Single-stranded DNA

Question 3

Specific amino acids bind to:

Answer 3

tRNA

Question 4

The transcriptome is composed of:

Answer 4

mRNA

Question 5

Alternative splicing, producing different gene products occurs on:

Answer 5

mRNA

Question 6

A protein with two peptide chains held together by cross links has this type of structure:

Answer 6

Quaternary

Question 7

Cis/trans and L/D isomers are proteins that differ in:

Answer 7

Tertiary structure

Question 8

Alpha helices and beta sheets are examples of which protein structure?

Answer 8

Secondary

Question 9

Sickle cell anaemia (HbS) is caused by:

Answer 9

An autosomal recessive inherited condition substituting an amino acid in the beta globin chain.

Question 10

In hypoxia, the abnormal HbS:

Answer 10

Polymerises

Question 11

The Hb structural change causes sickling by:

Answer 11

Binding the cytoskeleton

Question 12

Sickle cells causes capillary occlusion by:

Answer 12

Binding to and activating endothelial cells, causing inflammation.

Question 13

Capillary occlusion typically causes pain in:

Answer 13

Bone

Question 14

Sickle cell disease can be treated by hydroxyurea because:

Answer 14

It increases the synthesis of normal HbF (foetal Hb)