IAH6 - Adaptive immunity 2

Question 1

What does positive selection in the thymus ensure?

Answer 1

T cell has a function TCR that binds MHC

Question 2

What is negative tolerance?

Answer 2

Ensures TCR does not strongly recognise self proteins

Question 3

What is co-stimulation?

Answer 3

Activation of PRRs by PAMPs triggers expression of cell surface protein (co-stimulatory molecules) on APC

Question 4

Function of co-stimulatory molecules?

Answer 4

Support the ability of T cells to proliferate and differentiate into full functional form

Question 5

What cytokine promotes T cell survival and proliferation?

Answer 5

IL2

Question 6

3 classes of T cell effector responses?

Answer 6

Cytotoxic = CD8
Helper = CD4
Regulatory = both

Question 7

How do cytotoxic T cells cause cell death?

Answer 7

Release cytotoxins which induce apoptosis

Question 8

Function of

a) Th1
b) Th2
c) Th17
d) TFH
e) Treg

Answer 8

a) Activate macrophages = inflammation
b) Activate mast cells
c) re-enforce inflammatory response
d) Activate B cells
e) suppress immune response