IAH - Immune response to bacterial infections

Question 1

Function of Th17, Th1, Th2, TFH, Treg?

Answer 1

Re-enforcment of inflammation (innate)
Activation of macrophages
Activation of mast cells
Activation of B cells in lymph node
Suppression of immune response

Question 2

How do Th1 promote recruitment of macrophages?

Answer 2

Macrophages express NHC II and display complementary antigen, Th1 binds and releases cytokines (CD40, IFN gamma) - promoting activation and recruitment

Question 3

If pathogens resists the immune response what occurs?

Answer 3

Chronic inflammation

Question 4

What is the difference in response if APC expresses lots vs little MHC II?

Answer 4

Lots = drives Th1 response = activates macrophage
Little = drives Th2 response  = activates mast cells = not good for intracellular infections

Question 5

Why are mucosal surfaces vulnerable to infection?

Answer 5

Thin permeable layer excuse of physiological functions (absorption and secretion)

Question 6

What feature of mucosal surfaces in SI allows specialised antigen-uptake?

Answer 6

M-cell of Peyer’s patch

Question 7

What are the effector functions of mucosal surfaces?

Answer 7

Lots of memory T cells, IgA, commensal mcirobiotia

Question 8

3 properties of microbiota at mucosa

Answer 8

Synthesise AMPs
Stimulate epithelial cells to secrete AMPs
Compete with pathogens