IAH3 - Innate immune cell functions Flashcards
Name 2 primary lymphoid tissues
Red bone marrow and thymus
Where does haematopoiesis occur?
Red bone marrow
What molecules regulate haematopoiesis?
Cytokines and stromal cells
What 3 lines of haematopoiesis are there?
Lymphoid
Myeloid
Erythroid
What innate immune cell is made from lymphoid lineage?
NK
Name cells of myeloid lineage
Neutrophil, basophil, monocyte, eaosinophil
Function of thymus
T-cell maturation
Thymus is bilobed
Expalin
Cortex and medulla
Why is the cortex more densely stained than the medulla (of thymus)
T cells enter via cortex and get filtered as they move towards medulla
Function of secondary lymphoid tissue
Capture antigens and APCs from sites of infection and initiate innate immune response
What secondary lymphoid tissue protects against
a) blood-borne viruses
b) tissue infections
c) intestinal infections
d) pharynx
a) spleen
b) Lymph nodes
c) Peyer’s patch
d) tonsils
Function of germinal centres of the lymph nodes
activation, maturation, proliferation of T and B cells
How to identify Peyers patch?
Epithelial cells around it (ciliated)
How do Peyer’s patches differ in structure to thymus and lymph nodes?
No fibrous capsule
How can tonsils be distinguished histologically?
Salivary glands
