IAH revision session - immunoglobulin (antibodies)

Question 1

Key difference between Ig classes?

Answer 1

Different heavy chains

Question 2

Where is IgG concentrated?

Answer 2

Serum

Question 3

Which Ig is the first to be produced?

Answer 3

IgM

Question 4

Which Ig is pentameric?

Answer 4

IgM

Question 5

What Ig takes over after the initial infection?

Answer 5

IgG

Question 6

What are the 2 forms of IgA?

Answer 6

Monomeric - in the blood

Dimeric = mucosal (secretory) = the major one

Question 7

How does IgE bind to mast cells?

Answer 7

Fc receptor

Question 8

What is the function of IgE?

Answer 8

Degranulate mast cells (during hypersensitivity)

Question 9

What is hypersensitivity a consequence of?

Answer 9

Advanced immune system against parasites (mast cells degranulate)

Question 10

What is the consequence of degranulated mast cells?

Answer 10

Activation of innate immunity - increased blood flow, neutrophil migration (inflammation)
Histamine release

Question 11

What T cells is involved in B cell activation?

Answer 11

TFH

Question 12

Where are B cells activated?

Answer 12

Germinal centre of lymph nodes

Question 13

What is clonal selection?

Answer 13

Proliferation and differentiation of the specific B cell

Question 14

What is the difference between B cells and plasma cells?

Answer 14

B cells can differentiate into plasma cells so they secrete all the IG (don’t have any not the surface)

Question 15

Function of isotope switching?

Answer 15

Make sure the response is appropriate

Improve immune response after encounter

Question 16

What is somatic hypermutation?

Answer 16

Increased rate of mutation in the variable region to refine it and give it a greater affinity

Question 17

What is recombinase activating gene?

Answer 17

The gene that controls all of the recombination/rearrangement of antigen receptor genes in the bone marrow