IAH - Adaptive immunity III

Question 1

What T cells helps activate B cells?

Answer 1

TFH

Question 2

What is the result of B cell maturation?

Answer 2

Differentiation into plasma cells - secrete Ig - no on surface

Question 3

Antibody funciton (4)

Answer 3

Activate complement
Target bound antigens to other branches of immune system (phagocytose, NK)
Neutralise toxins
Prevent pathogens binding surface fo cell and enetering

Question 4

Difference in Ig classes?

Answer 4

Heavy chain

Question 5

Most abundant Ig?

Answer 5

IgG

Question 6

First Ig made?

Answer 6

IgM

Question 7

Pentameric antibody?

Answer 7

IgM

Question 8

2 forms of IgA?

Answer 8

Monomeric (in the blood)

Dimeric (mucosal surfaces - secreted)

Question 9

How does IgE bind mast cells?

Answer 9

Fc receptor

Question 10

Effect of IgE on mast cells?

Answer 10

Degranulation

Question 11

How is correct B cells selected?

Answer 11

Clonal selection

Question 12

How is diversity in antibody binding regions generated?

Answer 12

Somatic recombination of genomic DNA (lots of different genes)

Question 13

What phenomena increases the affinity of the binding region as infection persists?

Answer 13

Somatic hypermutation (high rate mutations in variable region)

Question 14

What is the purpose of isotope switching?

Answer 14

Appropriate response e.g. infection of mucosa = IgA

Question 15

Other than plasma cells what can B cells differentiate into?

Answer 15

B memory cells = important for adaptive immunity