Hypertension in Pregnancy Flashcards
How many pregnancies will hypertension affect?
10-15%
Who is PET most likely to affect?
Primigravida
What is the commonest cause of iatrogenic prematurity?
PET
Describe the CV changes in pregnancy
Plasma vol increased by 45% CO increased by 30-50% SV increased by 25% HR increased by 15-25% PVR increased by 15-20%
How will BP change in pregnancy?
Mid pregnancy dip in 2nd trim
Progressive risk in HR
Definition of hypertension in pregnancy?
> 140/90 on 2 occasions
>160/110 once
What are the different forms of hypertension in pregnancy?
Pre-existing hypertension (PEH)
Pregnancy induced hypertension (PIH)
Pre-eclampsia (PET)
What is pre-existing hypertension?
Diagnosis prior to pregnancy
If hypertx before 20 weeks; nothing to do with baby
What are the secondary causes of PEH?
Renal/ cardiac anomalies
Cushing’s
Conn’s
Phaeo
What are the risks to PEH in pregnancy?
Double the risk of developing PET
IUGR
Abruption
When will PIH resolve?
Within 6/52 of delivery
What differentiates PIH from PET?
Hypertension with no other features such as proteinuria or pre-eclampsia
Cardinal signs of pre-eclampsia?
Hypertension
Proteinuria (>0.3 g/l or >300 mcg/24hr)
Oedema
What causes pre-eclampsia?
Diffuse vascular endothelial dysfunction with widespread circulatory disturbance
Can affect; renal/ hepatic/ CV/ haematology/ CNS/ placenta
Describe early pre-eclampsia?
<34 weeks
Assoc with extensive villous and vascular lesions of placenta
Higher risk of maternal and foetal complications that late PET
Deswcribe late PET
> 34 weeks
Minimal placental lesions
Maternal factors (metabolic syndrome and hypertx)
What is stage 1 of the pathogenesis of PET?
Abnormal placental perfusion resulting in placental ischaemia
Failure of placentation and trophoblast invasion and thinning of spiral arteries resulting in a high resistance, low flow placenta
What is stage 2 of the pathogenesis of PET?
Widespread endothelial damage and dysfunction
Endothelial activation resulting in increased capillary permeability, increased expression of CAM, increased prothrombotic factors, increased platelet aggregation, increased vasoconstriction
What is one of the central pathogenic mechanisms in pre-eclampsia?
Imbalance of angiogenic and antiangiogenic factors
Endothelial dysfunction
What symptoms can PET present with (as a multisystem disorder)?
CNS; seizures Renal; AKI Hepatic; HELLP Haematological; HELLP, DIC Pulmonary oedema CV; hypertx, cardiomyopathy Placental; insufficiency and infarction (IUGR, abruption, stillbirth)
Si and Sy of HELLP?
Epigastric/ RUQ pain
Hepatic capsule rupture -> intra-abdominal haemorrhage
Abnormal liver enzymes
What does HELLP stand for?
Haemolysis
Elevated Liver enzymes
Low Platelets
What can placental disease result in?
FGR
Placental abruption
Stillbirth - IUD
Symptoms of PET?
Headache Visual disturbance Epigastric/ RUQ pain N+V Rapidly progressive oedema
Signs of PET
Hypertx Proteinuria Oedema Abdominal tenderness Disorientation SGA IUD Hyperreflexia/ involuntary movements/ clonus
Describe a praevia vs abruption?
Praevia; painless antepartum haemorrhage
Abruption; painful antepartum haemorrhage