Hypertension in Pregn. Flashcards
How common is hypertension in pregnancy?
10-15% of all pregnancies
How common is severe pre-eclampsia?
- only affects 1% of primigravid women
- whilst mild pre-eclampsia affects 10% of primigravid women
What is the biggest cause of iatrogenic pre-term birth?
- Pre-eclampsia
How does the maternal CVS system adapt to pregnancy?
- increase in plasma volume (50%)
- incr. in CO, SV, HR
- decr. in peripheral vascular resistance (15-20%)
Trends in BP and HR in Normal Pregnancies?
- mild dip in BP in Mid-trimester of the pregnancy
- progressive rise in HR by 7 bpm (not sudden!)
What is hypertension define as?
- > 140/90mmhg on 2 occassions
- >160/110 mmHg once
How to dx pre-existing H/T?
- if H/T does not resolve within 3 months of delivery
Risks of pre-existing htn?
- PET (pre-eclampsia) x2
- IUGR
- placental abruption
What are fts of pregnancy induced htn?
- no proteinuria/ other PET fts
- better outcomes than PET
- but 15% progresses into pre-eclampsia
- recurrence is high
How does pre-eclampsia present as?
- htn
- proteinuria
- edema
- —-absence of ONE of these 3 fts does NOT exclude PET dx
How does PET affect blood vessels?
- d/t endothelial dysfxn in whatever system is affected (renal/ hepatic/cvs/hematology/cns/placenta)
How diff. is early pre-eclampsia vs late pre-eclampsia?
- EARLY (<34wks) : HIGHER risk of maternal and FETAL complications/ uncommon/ a.w extensive villous and vascular lesions of the placenta
——LATE : majority/ minimal placental lesions/ maternal factors important (metabolic syndrome) /most caseECLAMPSIA AND MATERNAL DEATH!
How does pre-eclampsia come about?
- insufficient blood flow to the placenta secondary to INADEQUATE remodelling of spiral arteries of the uteroplacental vascular bed
- trophoblasts normally cause a change in the endothelium by invading the musculoelastic walls; to allow blood for the fetus to be well recieved
- in pre-eclampsia: d.t failure of normal vascular remodelling, Spiral arteries fail to adapt to become high capacitance, low resistance vessels
What liver conditions does pre-eclampsia cause?
epigastric/ RUQ pain
- hepatic capsule rupture
Hemolysis
Elevated Liver ENzymes
Low Plates
How does placental abruption present as?
- painful ante-partum hemorrhage
What placental disease may arise from hypertension?
FGR
Placental abruption
- Intra-uterine death
Symptoms of pre-eclampsia?
- Headache
- Visual disturbance
- Epigastric / RUQ pain
- Nausea / vomiting
- Rapidly progressive oedema (can’t fit rings in)
- loss of vision!
What are the signs of pre-eclampsia?
Hypertension Proteinuria Oedema Abdominal tenderness Disorientation Small for Gestational Age (SGA) Fetus Intra uterine fetal death Hyper-reflexia / involuntary movements / clonus ----painless ante-partum hemorrhage= low-lying placenta
Ivx for pre-eclampsia?
Urea & Electrolytes Serum Urate Liver Function Tests (HELLP $) Full Blood Count (hemolysis and thrombocytopenia) Coagulation Screen Urine - Protein Creatinine Ratio (PCR) (>30 ) Cardiotocography Ultrasound - fetal assessment
How to manage pre-eclampsia?
Assess risk at booking - identify risk factors
- if Hypertension < 20 weeks - look for secondary cause (renal disease, echo-cardiac scans)
- Antenatal screening - BP, urine, MUAD
- Treat hypertension
- Maternal & fetal surveillance
- Timing of Delivery
Risk factors of pre-eclampsia?
>40y.o BMI >30 Family hx (up to 40% if sis is affected/ 25% if mum) - parity (1st pregn: 2-3x) multiple preg. (twins 2x) previous pre-eclampsia (7x) BIRTH interval >10 years Molar preg./ triploidy - multiparous women
Medical risk factors for pre-eclampsia?
Pre-existing renal disease Pre-existing hypertension Diabetes (pre-existing/gestational) Connective tissue disease Thrombophilias (congenital / acquired- lupus anti-coagulant)
How does aspirin help in pre-eclampsia?
- inhibits Cyclo-oxygenase; prevents TXA2
- —-prevents thrombosis in placental blood vessels; saves perfusion of placenta
What is the dose of aspirin given, to whom and for how long ?
- used on HIGH risk women (renal disease, DM, aPS/SLE, multiple risk factors)
- 150mg dose
- commence before 16 wks
Why does peripheral resistance reduce in pregnancy?
High resistance low capacity > low resistance high capacity blood vessels
When can pre-eclampsia be dx on the Maternal Uterine artery doppler?
20-24 weeks
—–HOW DOES it appear: as a notch
When to refer to antenatal Day care unit?
- proteinuria ++
- ^^edema
- persistent headache
BP >140/90
When to admit to ward?
- BP >170/110 OR >140/90 w. proteinuria
- Significant symptoms - headache / visual disturbance / abdominal pain
Abnormal biochemistry
Significant proteinuria - >300mg / 24h
Need for antihypertensive therapy
Signs of fetal compromise
Inpatient assessment involves what investigations?
Blood Pressure - 4 hourly
Urinalysis - daily
Input / output fluid balance chart
Urine PCR - if proteinuria on urinalysis
Bloods - FBC, U&Es, Urate, LFTs. Minimum X2 per week
What is recommended when treating hypertension?
Aim to bring the BP down slowLY, d.t risk of hypoperfusion to fetus (aim for 140-150/90-100)
Hypertensive medication c.i in pregnant ladies?
- diuretics and ACE-Is
How is the fetus assessed?
- fetal movements
- CTG
- USG (biometry/ AFI/ umbilical artery doppler)
What to check for on the umbilical artery doppler?
- in 3rd trimester pregnancy
- —-with incr. reisstance; - loss of flow during disatole and reversal of blood flow
When to deliver the baby?
- mother to be stabilised
- 2 DOSES OF DEXAMETHASONE (if pre-term)
- —most should be delivered in 2weeks of dx
Indications for birth?
Term gestation
Inability to control BP
Rapidly deteriorating biochemistry / haematology
Eclampsia
Other Crisis
Fetal Compromise - abnormal Ultrasound or CTG
Rx of eclampsia ?
- IV LABETOLOL
- IV HYDRALAZINE
—–continuous perfusion; beware of hypotension
Fluid balance is a MAIN cause of maternal death and fluid challenges are potentially dangerous….
What is done to manage fluid overload?
- run the pt dry : 80ml/h
What is involved with the management of Pre-eclampsia?
- contorl BP
- prevent seizures
- fluid balance
- delivery
Cause of 14% of maternal deaths?
hypertension
Secondary causes of pre-existing hypertension?
- renal
- cardiac
- Cushing’s
- Conn’s
- Phaeochromocytoma
Local vasospasm d/t pro-inflammatory release from the placenta results in various multisystemic symptoms. What are they?
- kindeys: oligouria, proteinuria
- Retina: scotoma, flashing lights, blurred vision
- Liver: injury and swelling, elevated liver enzymes, capsule stretching (RUQ pain)
How does hemolysis come about in pre-eclampsia?
- numerous thrombi form d.t to the dysfunctional endothelium
- cause break down of RBCs
- —-thrombi may also use up the platelets!
Why does generalized edema arise in pre-eclampsia? How does it present as?
- endothelial dysfxn causes vascular permeability
- with reduced oncotic pressure; MORE FLUID loss in to the tissues
- seen in legs, face and hands
- —PULMONARY edema: cough, sob
- —-cerebral edema: headache, confusion and seizures
What pro-inflammatory factors are released by the placenta when hypoperfused?
- VEGF
- sEng
- Flt1
- PIGF
How effective is ASPIRIN?
- 15 % reduction of PET
- more beneficial in preventing SEVER early onset of pre-eclampsia
WHat is the 1st line rx of hypertension?
- Methyldopa (c.i in Depression)
- LABETOLOL
- Nifedipine (SR)
What hypertensive drug should be avoided in an asthmatic pt?
Labetolol- beta blocker
Which hypertensive drug should be avoided in a depressed pt?
- Methyldopa
Name 2nd line hypertensive rx?
- Hydralazine (vasodilator)
2. Doxazocin (alpha-blocker)
Which drug should be avoided when breastfeeding?
- doxazocin
What complications may arise in Pre-eclampsia?
- eclampsia
- HELLP $
- Pulm. Edema
- Placental abruption
- cerebral hemorrhage
- Cortical blindness
- DIC
- Acute renal failure
- hepatic failure
WHat is eclampsia?
Pre-eclampsia with seizures
- –tonic-clonic (grand mal) seizure
- —>1/3 will have seizure BEFORE HTN onset/proteinuria
In whom is eclampsia commonly seen in?
And what is eclampsia commonly a.w?
- seen in Teenagers
- a.w vasospasm
Why is fluid balance important in pre-eclamptic management?
- pulm. edema is the main cause of death
How is labour and birth any diff. in a case of eclampsia?
- aim for vaginal birth
- control BP
- epidural anaesthesia
- continous fetal monitoring!
- AVOID ergometrine
- caution with IV fluids
What management is provided post-partum?
Breast feeding Contraception BP management Counselling / debrief Future risk ----gestation dependent Consider long term CVS risk