HMG-CoA Reductase Inhibitors Flashcards
1
Q
Atorvastatin
A
Lipitor
2
Q
Lovastatin
A
Mevacor
3
Q
Pravastatin
A
Pravachol
4
Q
Rosuvastatin
A
Crestor
5
Q
Simvastatin
A
Zocor
6
Q
MOA
A
Blocks synthesis of cholesterol in liver by competing with HMG-CoA reductase, rate limiting enzyme in cholesterol production
7
Q
Common Adverse Effects
A
Myalgias, arthralgia
fatigue
diarrhea
8
Q
Rare Adverse Effects
A
Myopathy/rhabdomyolysis
9
Q
Counseling Pts.
A
Avoid grapefruit juice.
Avoid large quantities of alcohol.
Take med at night (lova, prava, simva).
10
Q
Clinical Pearls
A
Lower LDL & TG
Increase HDL
First line therapy for anyone with hyperlipidemia or CVD.
drug-drug interactions
