Hirschsprung Disease ( Gi Dysfunction)

Question 1

Hirschsprung disease

Answer 1

Absence of ganglion cells which causes an absence of peristalsis , and loss of rectosphincteric reflex

Question 2

What can the absence of ganglion cells cause?

Answer 2

Stool accumulation leading to mega colon leading to intestinal ischemia and entercolitis

Question 3

Entercolitis

Answer 3

Damage to mucosal cell lining valve wall
Will decrease blood supply and lead to cell death

Question 4

What diagnoses hirschsprung diasease

Answer 4

X-ray is going to assist in diagnosis but true confirmation is through rectal biopsy

Question 5

What are they looking for in rectal biopsy

Answer 5

Absence of ganglion cells

Question 6

What does hirschsprung disease get mis diagnosed for?

Answer 6

Chronic constipation and is initially treated for various forms of constipation

Question 7

Clinical manifestations of Hirschsprung disease in an infant

Answer 7

Failure to pass meconium
Abdominal distention
(From not passing stool)
Feeding intolerance / vomitting

Question 8

If an older child gets past infancy what are the manifestations?

Answer 8

Constipation
Diarrhea
And or ribbon like could smelling stool
Easily palpable stool mass

Question 9

Surgery for Hirschsprung

Answer 9

Endorectal pull through
When they basically cut out the not good part of colon and pull down the healthy one and connect that one

Question 10

Go back to recording on preop and post op