Herpesviridae Flashcards
0
Q
Genome of herpes?
A
Double stranded
Linear
1
Q
Describe virion of herpes?
A
Icosahedral
2
Q
Three subfamilies of herpes?
A
Alpha
Beta
Gamma
3
Q
Rapid growth?
A
Alpha
4
Q
Slow growth?
A
Beta (bagal)
5
Q
Latency in sensory ganglia
A
Alpha
6
Q
All herpesvirus have identical MORPHOLOGY and cannot be distinguished under what?
A
EM
7
Q
Latent infection for alpha?
A
Neurons
8
Q
2 genus of alpha
A
Simplex
Varicello
9
Q
Official names of all alpha
A
HHV 1-3
HHV 1 - HSV1
HHV 2 - HSV 2
HHV 3 - VZV
10
Q
Genus for beta
A
Cytomegalo
Roseola
11
Q
Genus for gamma
A
Lymphocrypto
Rhadino
12
Q
Common names for beta
A
CMV (HHV5)
HHV6
HHV7
13
Q
Hsv 1 and 2 genome share?
A
50-70% homology
Cross reactive epitopes with each other and VZV
14
Q
Only natural host for HSV
A
Man
15
Q
Most common form of infection results from a KISS given to a child
A
HSV
16
Q
Generally HSV 1 causes infection where?
A
Above the belt
17
Q
40% of genital sores are?
A
HSV1
18
Q
Primary infection or reactivation HSV?
- short lived viremia
- spread to the craniospinal ganglia
- irradiation or psychological stress
A
Primary
Primary
Reactivation
19
Q
Most common manifestation of 1• herpetic infection
A
Acut gingivostomatitis
20
Q
What is the manifestation of acute gingivistomatis?
A
Pain and bleeding of gums
21
Q
Recurrence of oral hSv
A
Herpes labialis
22
Q
Lesions found in herpes labialis
A
Papules then vesicles
23
Q
Vesiculoulcerative lesion; prone to 2• bacterial infection
A
Genital herpes
24
Common conplaint with genital herpes
Dysuria
25
One of the most serious complications of herpes simplex
Ensephalitis
26
2 forms of herpes simplex encephalitis
Neonatal
| Focal disease
27
Global involvement; brain is liquified
Neonatal
28
In focal disease what part of brain is usually involed
Temporal
29
Given in all cases of HSE
Acyclovir
30
Baby usually infected perinatally during passage thru birth canal
Neonatal herpes simplex
31
In neonatal herpes simplex, most common organs involved
LAB
LIVER
Adrenals
Brain
32
Only means of prevention for neonatal hsv
Cesarian to mothers
33
3 categories of disease of neonatal herpes simplex
Lesions in skin; disseminated ds to organs; enceph
34
Occurs in immunocompromised and resembles chicken pox
Disseminated herpes simplex
35
Other cutaneous manifestations pf herpes simplex?
Zosteriform
Eczema herpeticum
Herpetic whitlow
36
Rare presentation of herpes simplex wherein dermatomal distribution
Zosteriform
37
Lesions that typically affect the fingers( dentists and hospital staff)
Herpetic whitlow
38
Rapid result but cannot distinguish bet hSV and Vzv
EM of vesicle fluid
39
Can distinguish bet HSV and VZV
ImmunoF of skin scrapings
40
Definitive diagnostic approach for HSV
Virus isolation!!
41
Mgt for hsv that is oral only and more expensive than acyclovir
Famcyclovir
| Vala"
42
Main target organ of varicella
Skin
43
Vzv becomes latent in the?
Cerebral or dorsal root ganglia
44
Vzv entry via?
Respiratory tract
45
True or false?
| Diagnosis of varicella is made on clinical grounds alone
True
46
Most common conplication of varicella
Bacterial innfection
47
Earliest symptoms of varicella
Malaise and fever
48
Order of rash site?
Trunk, face, limbs, mouth
49
Also known as shingles
Herpes zoster
50
Intensive pain in zoster that may last for months
Postherpetic neuralgia
51
Zoster transmitted to the fetus in the first 20weeks (very rare!!)
Congenital vzv infection
52
Vzv can cross the placenta on later stages to infect fetus leading to
Neonatal varicella
53
Zoster Ig should be given to?
Pregnant who had contact with vzv cases;
| Infants whose mothers had it 7days before delivery or upto14 days after delivery
54
Vesicular fluid bet the 2 can be differentiated in EM
HSV and Pox
55
Antiviral thrapy only given to these vzv patients
Gt 50 years!!
56
Beta herpes virus that is Very species and cell type specific
Cmv
57
Only known host for cmv
Humans
58
Once infected virus remains in the person for life and nay be reactivated from TIME to TIME
Cmv
59
Perinatal infections of cmv occurs at
Genital secretions or breast milk
60
Postnatal infections of cmv occurs at?
Saliva
61
Syndrome of infective mononucleosis
Fever
Lymphadenopathy
Splenomegaly
62
Second most common cause of ment handicap, next to trisomy 21
Congental CMV infection
63
Candidate vaccine for CMV
Towne strain
64
Major target cell of ebv
B lymphpcyte
65
Ebv receptor in cells
Cr2 or cd21
66
Three classes of ebv antigens
Latent phase;
| Early; late
67
Ebv: Nonstructural proteins whose synthesis is nlot dependent on viral DNA replication
Early
68
Ebv: includes ebna and lmp
Latent phase antigens
69
Ebv is transmitted via
Saliva( kissing)
70
2 disease association of ebv in aids patients
Oral leukoplakia
| Chronic interstitial pneumonitis
71
These atypical cells are present in the blood in IM
Downey cells
72
Diagnosis of IM?
Heterophil antibody test pr
| Detn of igM
73
Malaria infection is a cofactor
Burkitts lymphoma
74
Gene that is associated w burkitts lymphoma
C myc
75
Malignant tumor of the squamous nasopharynx; most common tumor in men;
Nasopharyngeal Ca
76
Occurs exclusively in males who had inherited a defective gebe in the X chrom; accts for half the fatal cases of IM
Ducan x linked
77
Screen for early lesions of npc and monitoring treatment
AntiEBV VCA IgA
78
Vaccine developed for ebv
MA antigeb gp 340/220
79
Main target cell for hhv7
T cells
80
Genome resembles cmv
Hhv6
81
Cell receptor for HHV6
CD46
82
HHV6 and 7 transmitted thru
Saliva and breast feedingg
83
As early as what age does hhv 6 and 7 occur?
4 mos old
84
Reactivation common in transplant px and during pregnancy
HHV6
85
Disease associated with HHV 6and 7
Roseola infantum ( 6th ds or exanthem subitum)
86
Cause of roseola from hhv 6
6B variant
87
Its genome is 75% G + c, highest among all herpesvirus
B virus
88
Disease in humans by B virus
Acute ascending myelitis
| Encephalomyelitis
