4B-3 Flashcards by karla villasin

Only Char of prions same with virus

FP
Filterable infectious
Presence of proteins

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Spongiform encephalopathy

Prions

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Prototype

Scrapie

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Difference of prpsc and prpc

Sc:
Multimeric
Location-cytoplasmic

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How do they cause dse?

Template mediated protein refolding

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Prpc is encoded in what chromosome

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Strains of prpsc continues how?

Mutate prpc

Self folding of prpsc

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Determines severity of cjd

Cdon 129

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Appearance of vacuolated neurons, loss of fcn, no immune

Spongiform enceph

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Protein marker seen in csf

14-3-3

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Incubation perood?

Long, 30 yrs

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Transmission?

Fict
Food
Injection
Contact thru medical dvce
Transplantation

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Ibheritable dseases

CJD
FFI
GSS

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Means shivering dse

Kuru

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Dse w sporadic occurence

Gss

Cjd

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CharacteriZed by loss of muscle cobtrol, myoclonus, tremors

spongiform enceph

Dx of prions

Proteinase K resistant at wblot

PMCA ( initiate polymern of prp)

Disinfection??!

HAS
Hypochlorite
AUTOCLAVE
Sodium OH