4-2 Rhabdo Flashcards
5 proteins encoded by genome?
N P mP G L
Describe mononega
Non segmented
Ss rna
Nega
2 major structural proteins
Rnp
Envelope
Protein for neuroinvasiveness and pathogenicity
G
Mainly in wildlife in______ countries
Developed
2 epid forms
Urban
Sylvatic
Rare form of transmission
Aerosol in halation
T orF ? It is possible for rabies to go ditectly to the nervous system w/o local replication
T
Organ w highest titers of virus
Submaxillary
Specific eosinophilic inclusion body (pathognomonic)
Negri body
T or f? Absence of negri rule out rabies
F
2 forms of prodromal sx
Encephalitic
Paralytic (dumb)
What form has hydrophobia and aerophobia
Furious type
What kind of paralysis in dumb type?
Flaccid
Ascending
Symmetric
Most rapid skin biopsy
F aBs
TorF? There are pathognomonic findings in imaging?
F
Biopsy specimen in humans obtained from? Animals?
Nape
Brain!
T or F? Blood contains virus
F
WHO categories of exposure?
1,2,3
Mgt for cat1
Wash, no vaccine, preEP may be needed
What category?
- licks on broken mucosa
- unprotected handling of carcass
- ingestion of raw meat
- sharing utensils w px
3
3
3
1
Rig is only indicated in what cat?
3 plus cat2 if immunocompromised
Thai red crosa Sked for active immunization
Day 0,3,7,28
One dose should be at least ______ vaccine potency
0.5 IU
Essen regimen?
Day 0,3,7,14,28
0,0,7,21
Zagreb regimen
0,7,30 (8 doses, 4doses, 1dose)
Oxford regimen
How many RIG doses given ?
1
If immunized mt 3 years, and ab titer is less than 0.5, booster needed?
Yes
Bites requiring PEp
Domestic
Livestock
Wild animals
Booster regimen
Day 0,3
Specimen for antibody detection
Serum
