4-3 Paramyxo Flashcards
Slam is also known as
Cd150
Measles H can bind to what cell?
Cd46 and cd150
Slam regulates _______ responses
TH1 and TH2
Major internal protein
Nucleoprotein
Associated with NP
L and P ( polymerase phosphoprotein)
Transmembranous envelope glycoprotein
F and H
Inside virion envelope
Matrix
Part of trabscription complex
Phosphoprotein polymerase
Measles Rash is caused by what cells?
T cells
Sequelae in cns resulting frkm development of defective mutants
Sspe
Persistent infection w/o lysis can occur in what cells?
Human brain cells
What happens after inoculation in the respi tract
Local replication
Acts as a slow virus and causes sx and cytopath effect in neurons years after
Sspe
T cell deficient children have atypical presentation
Giant cell pneumonia w/o rash
Interferon a and b activates what?
NK cells
What IL is depressed in measles?
IL12
Can be administered after exposure
Immmunoglobulin
Transmission of measles
Large droplets
Measles most infectious at what stage
Prodrome
Prodrome starts w?
High fever
4Cs
Photophobia
Most commonly seen in the buccal mucosa, other mucous membranes
Koplik spots
Clinical consequences of measles
MAPS: Measles Atypical PME SSPE
Rashes prominent in distal areas
Atypical measles
Serious complication of measles accounts for 60% deaths
Pneumonia
Occured in people who recrived older inactivated vaccines
Atypical
Recommended specimens for measles
Respi secretions
Urine
Blood
Brain
What Ig is detected greatly at prodrome
IgM
Current vaccine used
Schwart or moraten
People who should not receive mmr?
Pregnant
Immunosuppresed
Gelatin/myocin
Reduces high risk of measle mortality
Vit A
Mumps vaccine?
Jeryl lynn strain
Mild coldlike symptoms
Para influenza virus
Types 1-3 causes?
Second only to rsv to cause severe lower rti
Type 4 causes?
Mild UPPER respi infection
Para influenza especially assoc with
CROUP
Unlike measles parainfluenza rarely cause
Viremia
CMI in parainfluenza causes what?
Both cell damage and protection
T or f? Reinfection in parainfluenza
True, milder
T or f? Parainf induced protective immunity that is long lived
False
A para influenza in infants most notably cause
Croup
Subglottal swelling which may close the airway
Croup
Principal ddx is epiglotitis by Hib
Parainfluenza
Specimen for parainfluenza
Nasal washings and respi secretions
To determine specific serotype of parainfluenza
HIB test
Method of choice to detect parainfluenZa
Rt pcr
Mumps most closely associated to?
Parainf type 2
How is the parotid gland infected?
Way of stensens duct
Viremia
T or f? In mumps, viremia occurs.
T
Where are the sites of viremia
Testes Ovary Pancreas Thyroid Etc
Transmission of mumps?
Direct person to person;
Rspiratory droplets
T or f? Swelling of other glands may occur without parotitis
T
Virus may cause asymptomatic shedding
Mumps
How to confirm diagnosis of mumps?
Serology, 4fold increase in igM
Rsv is the Most common cause of
Fatal acute respiratory infrction
T or F? Maternal antibody protects infant from infection
F
Necrosis of bronchi which leads to formation of plugs
Rsv
T or F? Rsv epidemic occur every year
True!! Unlike influenza!!
Can also be transmitted by fomites
RSv
Infants w rsv
Lrti
Modes of control of rsv
Immuno globulin;
Aerosol ribavirin
Clinical cnsequence of rsv
Bronchiolitis/pneumonia;
Febrile rhinitis and pharyngitis;
Common cold
Only virus diff to culture
RSv
And metapneumo
New paramyxo
Nipah and hendra
