Herpes Viruses Flashcards
What holds the herpes viruses latent
cell mediated immune response
What effect of herpes viruses have on the immune system
cytopathic
become multinucleate syncytial cells with intranuclear inclusion bodies
where do the herpes viruses hang out being latent
in the sensory ganglia
what supset of herpes viruses cause cell destruction
the alpha group
herpes simplex 1 and 2
herpes zoster
what are the other herpes viruses and their corresponding subtypes
CMV is beta
EBV is gamma
how does transmission of herpes simplex 1 and 2 occur
direct inoculation of much-cutaneous surfaces
What are some of the clinical manifestations of herpes siplex
gingivostomatitis genital herpes herpetic keratitis neonatal herpes herpetic whitlow disseminated herpes encephalitis
what are the signs of gingivostomatitis
painful swollen gums and mucous membranes with vesicles
fever and systemic symptoms
resolve in 2 weeks
what are the signs of genital herpes
fever, HA, vaginal and urethral discharge
enlarge d lymph nodes
blisters and painful or painless ulcers
what is the most common infectious cause of corneal blindness in the US
herpetic keratitis
what can neonatal herpes cause
transplacental viral transfer
congenital defects or intrauterine death
What is herpetic whitlow
HSV infection of the finger that is painful, hot, swollen and red
when does disseminated herpes happen? and where?
immunocompromoised patients
liver, lung and GI
what is the most common cause of viral encephalitis in the US
HSV-1
what are the signs of HSV-1 encephalitis
fever and focal neurological abnormalities
What are the TORCHES that cross placenta
Toxoplasmosis Rubella CMV Herpes HIV Syphilis
where does varicell ainfect and what occurs
infects respiratory tract then after 2 week incubation causes viral dissemination in blood
What are symptoms of varicella infection
fever, malaise, HA with characteristic rash that starts on face and trunk then spreads to entire body
What does the rash look like in Varicella
rose petal with dew on top(fluid vesicle)
becomes cloudy and ruptures then scab over
arise in crops or patches
Patient has hard red lesions that have central depression and seem to be all over the body in the same state
likely Dx?
small pox
How does shingles or zoster occur
stressed state or lowered cell mediated immunity the latent varicella zoster virus replicates and migrates to cutaneous nn
does singles occur in adults that have not had chickenpox
no the adults contract chicken pox
what adult vaccine is recommended for control of shingles
live attenuated varicella vaccine for adults 60+ whether or not have had shingles
What can zoster lead to in immunocompromised patients
pneumonia and encephalitis
