Helminths Flashcards

1
Q

What are nemotodes and what are playhelminthes

A

nemotodes are round worms

playhelminthes are flat worms

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2
Q

What intestinal nematodes are acquired by ingestion of eggs

A

Ascaris lumbricoides, Trichuris richuria and Enterobius vermicularis(pin worm

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3
Q

What round worms usually penetrate skin of feet

A

Necator amricanus and Stronglyoides stercoralis

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4
Q

What round worm is ingested in port meat with larvae

A

Trichincella spiralis

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5
Q

What round worms invade the lung at some point in their cycle

A

Ascaris lumbricoides, Necator Americanus and Stronglyoides stercoralis

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6
Q

Where and how do people acquire ascaris lumbricoides

A

mountainouse and tropical areas souther US

consume food with the eggs

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7
Q

Where do the larvae of Ascaris grow

A

in lung alveolie then coughed up swallowed and mature in intestines

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8
Q

What happens with the eggs of Strongyloides stercoralis

A

Autoinfection-larvae penetrate intestine directly
Direct cycle- larvae pass out in feces and infect next person
Indirect- in soil the filariform larvae develop into male and female adults then fertllze eggs and the larvae hatch and reinfect

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9
Q

What is involved in severe infections with Ascaris

A

worm invasion into bile ducts, gall bladder and appendix and liver
in lung have pulmonary infiltrate on CXR with high eosinphilia

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10
Q

Dx of any types of the worms?

A

eggs in feces

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11
Q

What drugs are used to treat intestinal nematodes

A

Mebendazole
Albendazole
Thiabendazole

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12
Q

To selectively target Enterobius or Necator or Ascaris what drug can you give

A

pyrantel pamoate

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13
Q

What can an infection by hookworms cause
Ascaris
Necator

A

iron deficiency anemia since suck blood

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14
Q

What do you avoid during Tx of Stronglyoides stercoralis

A

prednisone or other steroids because can result in severe auto infection of pneumonia ARDS and multi-organ failure

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15
Q

What is the enterotest

A

long nylon string is swalled and later pulled out of the mouth to see larvae of stronglyoides

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16
Q

What is the sensitive test for stronglyoides infection

A

ELISA Ab assay

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17
Q

Describe the cycle of Trichinella Spiralis

A

adult males are passed in feces

females penetrate intestinal mucosa and lay thougsands of larvae that enter blood and spread to organs and skel muscle

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18
Q

What are the symptoms of Trichinella Spiralis infection

A

1 week after intestinal invasian there may be fevers and musclar aches

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19
Q

How do you Dx trichinella piralis

A

serologic tests or muscle biopsy
Increase levels of eos
increased serum muscle enzymes like CPK

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20
Q

What is the whipworm

A

Trichuris trichuria

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21
Q

how come pinworm and whipworm do not have elvated eosinphilis

A

because there is no transit outside of the intestine

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22
Q

Where do the whip worm larvae adhere

A

cecum and ascending colon

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23
Q

Why is there no autoinfectino with whipworm

A

eggs need to incubate 3-6 weeks in soild before infective

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24
Q

PAtient has feces that have little football with bumps on the end

A

trichuris trichuria infection

whipworm

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25
Q

What are symptoms of whipworm infection

A

diarrhea and abdominal pain

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26
Q

What is the pinworm and where does it mature

A

Enterobius vermicularis

matures in the ascending colon

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27
Q

What is unique about the female enterobius worm

A

at night migrates to perianal area where she lays her egs causing severe perianal itching

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28
Q

How do you Dx pinworm

A

scotch tape test for eggs

29
Q

How are blood and tissue nematodes spread?

A

bites from arthropods

they are called filariae

30
Q

What are the prelarval filariae forms of tissue nematodes

A

microfilariae

31
Q

When do we encounter disease from tissue nematodes

A

when the microfilariae and adult worms are dead in lymphatic system
allergic reaction

32
Q

What are filarial parasites hosts to

A

Wolbachia bacteria

so we can target them to kill the parasites

33
Q

What filarial infection is common in Africa, Central and /south America in the black flies

A

Onchocerca volvulus

34
Q

what are signs of Onchocerca volvulus

A

pruritic skin rash with darkened pigmentation
papular lesions that are intraepithelial granulmomas
dry, scaly and thick
often migrates to eye causing blindness

35
Q

What is Tx for Onchocerca volvulus

A

ivermectin

36
Q

What tissue nematodes result in elephatiasis? and in what geographical areas?

A

Wechereria bancrofti- Pacific islands and Africa

Brugia malayi- Malay and SE asia

37
Q

What transmits the elephatiasis causing nematodes?

what is elephatiasis

A

mosquito

the lymph edematous areas become covered in a thick scaly skin

38
Q

What can frequent infections of Wechereria and Brugia cause

A

febrile episodes with HA and swollen inguinal lymph nodes’sometimes fibrosis in lymph areas

39
Q

How do you Dx Wechereria and Brugia

A

blood drawn and nighttime
Nocturnal periodicity
or Ab titers via immunofluorescence

40
Q

Tx for elephatiasis

A

Diethylcarbamazine

41
Q

What is the spp guinea worm

A

Dracunculus medinensis

42
Q

how do we prevent spread of guinea worm infections

A

avoid water because female releases eggs in water

43
Q

What is cutaneous larvae migrans

A

creeping eruption of pruritic skin from larvae of cat and dog hookworms
raised itchy rash

44
Q

How do you Dx what is causing a cutaneous larvae migrans

A

biopsy of advancing edge

45
Q

What are the 2 groups of flatworms

A

Trematodes and Cestodes

46
Q

What are other names for trematodes

A

flukes like schistosomes

47
Q

What are other names for cestodes

A

tapeworms

48
Q

Where do shistosomes invade human

A

venous system

49
Q

What is the name for mature schisostomal larvae

A

cercariase

50
Q

What form of schistosome can survive human immune system and why

A

adult worm- think there is molecular mimicry

the mature larvae and eggs stimulate immune response

51
Q

What are the 3 disease syndromes that occur sequentially from schistosomes

A

Dermatitis at site of penetration
Katayama fever when laying eggs
Chronic fibrosis of organs and blood vessels from chronic inflammation around deposited eggs

52
Q

Describe Katayama fever

A

4-8 weeks after penetration
fever, hives, HA, weight loss and cough for 3 weeks
lymph node and HSM with eoshinophilia

53
Q

What are sequelae of schistosome infection

A
portal HTN from blocking venous system
granuloma formation
ulvers
can have hematuria, chornica abdominal pain and diarrhea
brain or SC injury
54
Q

Tx for schistosome infection

A

praziquantel

55
Q

what is unique about tape worms

A

hermaphrodites

also need human as host because do not have true digestive tract

56
Q

What is the structure of tapeworms

A

Scolex- anterior head with suckers
Immature proglottids
mature proglottids- male and female
gravid proglottids- fertilized eggs

57
Q

How do you Tx tapeworm infection

A

praziquantel and niclosamide

58
Q

what tapeworm is at risk of infected pork meat

A

tanenia solium

59
Q

What is cysticercosis

A

when humand ingest the eggs of taenia solium not the encysted larvae
form cystercerci in brain and skel mm
leads to Neurocysticercosis

60
Q

What are symptoms of neurocysticercosis

A

seziures, obstructive hydrocephalus, focal neurologic deficits
after 5-10 years leak antigenic contents causing seizures, meningitis, hydrocephalus

61
Q

What areas of the world is neurocystercercosis most common cause of seizures

A

Mexico, Central and south america, Philippines and SE asia

62
Q

What labs help Dx neurocystercosis

A

CAT scan or biopsy of brain tissue

63
Q

What tapeworm is found in contaminated beef? and what is the risk if have it

A

Taenia saginata

generally benign, maybe malnutrition and weight loss

64
Q

What worm is found in salmon, trout and pike (freshwater fish)? what can it cause

A

Diphyllobothrium latum

can cause anemia because likes to absorbe Vit B12

65
Q

What is the dwarf tapeworm and what does it cause

A

Hymenolepis nana

abdominal pain, and occasionally nausea and vomiting

66
Q

Which worm forms cysts that can compress surrounding structures? what about if rupture

A

Echinococcus granulosus and multilocularis

inside is allergic causing fluid that may be fatal

67
Q

How do we Tx Echinococcus granulosus

A

surgical excision or instill saline. idophore and ethanol into cyst to kill contents

68
Q

What is the PAIR method for hydatid cysts

A

percutaneous aspiration infusion of scolicidal agents and reaspiration