Chap8- Viral Infections Flashcards
What viruses attack upper respiratory tract
adenovirus
rhinovirus
influenza viruses A B
Respiratory syncytial virus
What viruses affect the digestive tract
mumps rotavirus- childhood norovirus Hep A Hep B Hep D Hep C Hep E
What viruses cause systemic with skin eruptions
measles rubella varicella zoster Herpes simplex virus 1 Herpes simplex virus 2
What viruses cause systemic with hematopoietic disorders
CMV
EBV
HIV 1 and 2
What are the arboviral and hemorhhagic fever viruses
dengue virus1-4
yellow fever
what virus causes skin warts
papillomavirus
What viruses affect CNS
polio and JC
How do you confirm a measles Dx
detection of viral antigen in nasal exudate or urinary sediment
What type of virus is measles
ss RNA of the paramyxovirus family
What virus causes croup
parainfluenza virus
What cell R are associated with measles
CD46- C’ regulatroy protein that inactivates C3 converses
SLAM- involved in T cell activation
How does measles spread
respiratory droplets and from there can multuply in epithelial cells, endothelial, monocytes, macrophages, dendritic cells and lymphocytes
What does measles cause clinically
croup, pneumonia, diarrhea with protein-losing enteropathy, keratitis with scarring and blindness, encephalitis and hemorrhagic rashes in malnourished children
Most people develope what type immunity to measles
T cell, with hypersensitivity rash
What is the cause of measles morbiditiy and mortality rates
its immunosuppression resulting in secondary bacterial and viral infection
What are some of the late complications of measeles
subacute sclerosing panencephalitis and inclusion body encephalitis
What does the rash to measles look like and what causes it
blotchy reddish, brown rash on face, trunk and proximal extremities
from dilated skin vessels, edema and mononuclear perivascular infiltrate
What are the pathonomonic findings in measles
Koplik spots, ulcerated mucosal lesions in oral cavity near opening
Warthin-Finkeldey cells- multinucleate giant cells in lymphoid tissue
What are the 2 types of glycoproteins on the mumps virus
one with hemagglutinin and one with neuraminidase activities
Where does mump replicate
preferentially in activate T cells
travel in drained lymph
What are common signs of mumps
salivary gland pain and aseptic meningitis
Describe morphology of the parotitis in mumps
moist, glistening and reddish brown
diffusely infiltrated by macrophages, lymph and plasma cells which compress acini and ducts
some neutrophils and necrotic debris
Describe morphology mumps orchitis
swelling from edema and mononuclear cell infiltration with focal hemorrhages
can have ares of infarction leading to sterility
What does mumps look like in pancreas
fat necrosis and neutrophil rich inflammation
describe mumps encephalitis
causes perivenous demylination and perivascular mononuclear cuffing
What type of virus is polio
unencapsulated RNA from the enterovirus genus
What are the enteroviruses
coxsackievirus A and B, enterovirus 70, echovirus
How many strains are there of polio and what vaccines are available
3 strains
the salk formalin(killed) and sabin oral (attenuated live) have all 3
how is polio transmitted
oral fecal route
multipling in intestinal mucosa and lymph nodes
Why does polio only affect humans
uses human CD155 to gain entry
What group of viruses does west nile belong to
arbovirus of flavivirus group
Where does west nile replicate
in dendritic cells then migrating to lymph nodes where it can enter blood stream and potentially cross bbb
What is the double edge about CCR5
without it more prone to west nile
with it- can be affect by HIV
What are the symptoms of west nile if any
short lived febrile illness with HA and myalgia
maculopapular rash in some
What is found in brains of those who died of West nile
perivascular and leptomeningeal chronic inflammation with microglial nodes and neronophagia in temporal lobes and brain stem