Herpes simplex virus

Question 1

what is HSV responsible for?

Answer 1

cold sores and genital herpes

Question 2

2 main strains of HSV

Answer 2

1 and 2

Question 3

what happens after initial infection?

Answer 3

virus latent in sensory nerve ganglia

Question 4

where does HSV become latent?

Answer 4

trigeminal nerve ganglion with cold sores

sacral nerve ganglia - genital herpes

Question 5

3 things HSV can also cause

Answer 5

aphthous ulcers
herpes keratitis
herpetic whitlow

Question 6

how is HSV spread?

Answer 6

direct contact with affected mucous membranes

viral shedding in mucous secretions

Question 7

what is HSV1 associated with?

Answer 7

cold sores

Question 8

HSV1

Answer 8

contracted in childhood and remains dormant in trigeminal nerve ganglion
reactivates in times of stress

Question 9

HSv-2

Answer 9

genital herpes

STI

Question 10

signs and symptoms of genital herpes

Answer 10

ulcers or blistering lesions 
neuropathic pain 
flu-like symptoms 
dysuria 
inguinal LN

Question 11

diagnosing HSV

Answer 11

sexual contacts

viral PCR swab

Question 12

managing HSV

Answer 12

aciclovir

paracetamol/topical lidocaine/loose clothing/wash warm salt water

Question 13

risk of genital herpes in pregnancy

Answer 13

risk of neonatal herpes simplex infection

antibodies cross placenta and give fetus passive immunity

Question 14

treating primary genital herpes in pregnancy

Answer 14

aciclovir + prophylactic aciclovir

caesarean section

Question 15

treating recurrent genital herpes in pregnancy

Answer 15

prophylactic aciclovir