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HEMATOLOGY 2 SUMMER TERM > HEMOSTASIS AND STAGES OF HEMOSTASIS > Flashcards

HEMOSTASIS AND STAGES OF HEMOSTASIS Flashcards

1
Q

DEFINITION OF HEMOSTASIS

A
  1. vasoconstriction
  2. platelet adhession and aggregation
  3. coagulation andfibrinolysis
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2
Q

what are the three hemostatic components

A
  1. extravascular components
  2. Vascular components
  3. Intravscular components
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3
Q

involves platelets and coagulation factor

A

Intravascular components

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4
Q

Highly procoagulant

A

extravascular cells

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5
Q

highly depends on the size of blood vessel, thickness and integrity of endothelial cell lining

A

vascular components

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6
Q

provides back support and pressure on the injured vessel by means of swelling

A

extravascular components

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7
Q

factors in extravascular components

A
  1. bulk/ amt of surrounding tissue
  2. type of tissue
  3. tone of surrounding tissue
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8
Q

Stages of hemostasis

A
  1. Primary hemostasis
  2. Secondary hemostasis
  3. Fibrinolysis
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9
Q

What are the platelet function cascade

A

Adhesion- Activation- secretion- aggregation

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10
Q

Primary hemostasis

A
  1. Constriction of damaged blood vessel
  2. Plt fxn cascade
  3. Formation of a temporary platelet plug formation
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11
Q

Activates adhesion

A

PECAM
vWF

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12
Q

Activates the activation in plt fxn cascade

A

Collagen

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13
Q

Characteristic of primary hemostasis

A

Rapid , short lived response

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14
Q

Delayed, long term

A

Secondary hemostasis

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15
Q

Slow dissolution and removal of fibrin clot

A

Fibrinolysis

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16
Q

Inhibits platelet activation
Stimulates vasodilation
Anticoagulant

A

Prostacyclin

17
Q

Coats the endothelial cell surface and weakly and weakly enhances the activity of antithrombin III
Anticoagulant

A

Heparan sulfate

18
Q

Endothelial cell surface receptor for thrombin (binds and inactivates thrombin)
Enhance anticoagulant and fibrinolytic action of protein C
Anticoagulant
Fibrinolytic

A

Thrombomodulin

19
Q

Controls activation of the extrinsic pathway
Anticoagulant

A

Tissue pathway factor inhibitor

20
Q

Convert plasminogen to plasmin
Fibrinolytic

A

Tissue plasminogen activator

21
Q

Stimulates vasodilation
Reduce blood flow rate

22
Q

Required for platelet adhesion to site of vessel injury
Procoagulant

A

Vwf
(Weibel palade bodies)

23
Q

ICAMS
PECAMS
PROCOAGULANT

A

Adhesion molecule

24
Q

P selectins

A

Intercellular adhesion molecules

25
Q

PECAMS

A

Platelet endothelial cell adhesion molecules

HEMATOLOGY 2 SUMMER TERM (16 decks)

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