Question 1

The Hill Equation

Accepted Answer

Ys = (P02)nH / { (P50)nH + (P02)nH }

Question 2

Sickle Cell Disease is significant only in ___________state

Accepted Answer

homozygous

Question 3

Where does heme synthesis occur?

Accepted Answer

Bone marrow

Question 4

Haldane Effect CO2_______ affinity of Hb for oxygen CO2 stabilizes ___________ by reacting with terminal amino groups to form _______; these induce T-state CO2 also stabilizes deoxy-Hb by causing a_______

Accepted Answer

Lowers deoxyhemoglobin; carbomates pH drop

Question 5

2,3-BPG binding lowers O2 affinity by_________T-state

Accepted Answer

Stablizing

Question 6

Major hemoglobins in adults

Accepted Answer

Alpha, beta, delta, and gamma

Question 7

Sickle cell disease is caused by mutation in gene for_________ subunit of adult hemoglobin (Hb)

Accepted Answer

B

Question 8

_Myoglobin_ _Hemoglobin_ O2 ______ protein O2_________ protein Location? Location? of Hemes? of Hemes? of Globin Chains? of Globin Chains Allosteric effectors? Allosteric effectors? ________ Curve _________ Curve

Accepted Answer

Storage; carrier Muscle; erythrocyte 1; 4 1; 4 None; H+,CO2 2,3-BPG, Cl- Hyperbolic; sigmodial

Question 9

Major hemoglobins in embryonic state

Accepted Answer

Zeta, alpha, gamma, and epsilon

Question 10

Symptoms of Sickle cell disease

Accepted Answer

anemia swelling of extremities higher risk of stroke and infection

Question 11

CO Inhalation leads to nonfunctional ___________ and _________hypoxia, pO2 may be normal but ______is high.

Accepted Answer

Hb; tissue; lactic acid

Question 12

When are symptoms of Sickle Cell Disease seen?

Accepted Answer

Symptoms not seen until 6 months after birth

Question 13

BPG-induced shifts O2 dissociation curve to the ________

Accepted Answer

Right

Question 14

Does adult hemoglobin or fetal hemoglobin have a higher O2 affinity?

Accepted Answer

Fetal hemoglobin

Question 15

In blood, ___________is a major target for CO poisoning

Accepted Answer

Hemoglobin

Question 16

Interactions with _________must be broken for T-to-R transition to occur When 2,3-BPG is present, more __________ sites must be occupied to induce transition Gamma subunit of HbF lacks _______; affinity with 2,3-BPG less, and O2 moves from _________ Hb to _________.

Accepted Answer

2,3- BPG O2 His-143; maternal; HbF

Question 17

_________ = Globin alone. __________= Heme + the globin chain.

Accepted Answer

Apoprotein Holoprotein

Question 18

Abnormal Oxidation of Heme Iron Pathway

Accepted Answer

(Fe+3) ---\> HEMICHROMES ---\> HEINZ BODIES ----\> RBC LYSIS------\> Reticulocytes ↑, Bilrubin↑ (Jaundice), Hematocrit ↓

Question 19

Heme composed of __________ IX ring and _______ion Fe++ ion coordinated by 4_________atoms of ring, a proximal ______ residue and an ________molecule (in oxy-hemoglobin); 6th position empty in _________. ________ histidine H-bonds to the bound O2

Accepted Answer

Protoporphyrin; Fe2+ Nitrogen; histidine; O2; deoxyHb Distal

Question 20

Normal Adult Hemoglobin Each subunit adopts ________ fold; has no______; has ______ heme prosthetic group buried in crevice within subunit. The only charged residues in interior are histidine ______and ________, which bind_________or ________. __________ contacts between unlike subunits (ab) strongest: dimer of dimers Two a and two b subunits; a and b similar but not ______ ________protein; inhibited by ___, _____, ______, ______, which lower __________affinity

Accepted Answer

Globin; B-sheets; one E-7; F8; O2; Fe2+ Dimeric Identical Allosteric; H+; CO2; 2,3 BPG; Cl-; oxygen

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Hemoglobin Flashcards

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