Heme Flashcards
Best indicator for RBC loss?
reticulocyte count
What conditions lead to an elevated INDIRECT bilirubin?
Hemolysis
Gilbert’s syndrome
What are causes of microcytic anemia?
Sideroblastic
Thalassemia
Iron Deficiency
Chronic Disease
What is the most common cause of sideroblastic anemia with basophilic stippling?
Lead
What problems do patients with one alpha globin chain (Hgb H) have?
stillbirth (hydrops fetalis)
Another name for beta-thalassemia major?
Cooley anemia
What do people with Hgb H disease need?
Folic acid
Most common form of anemia?
Iron deficiency
What is the hallmark of iron deficiency?
Pica
What are the most common causes of a macrocytic anemia?
B12 and folate deficiency
Cell findings pathognomonic for folate deficiency?
macro-ovalocytes
hypersegmented PMN cells
Howell-Jolly bodies
Most common cause of folate deficiency?
diet
Most common cause of pernicious anemia?
Lack of Intrinsic Factor
What test looks for antibodies on RBC thus looking for hemolytic anemia?
Coombs
What stain looks for G6PD?
Heinz body
What daily / lifelong medication should be considered for all patients with sickle cell disease?
Hydroxyurea
What do atypical lymphocytes point towards?
EBV (mono)
What do Auer Rods point towards?
AML
What cells are pathognomonic for CLL?
smudge cells
Which cells point towards Hodgkin’s Disease?
Reed-Sternberg
What virus is seen in 50% of Hodgkin’s?
EBV
What is a trigger for lymph node pain in Hodgkins?
pain after alcohol
Where is the pathology in multiple myeloma?
plasma cells
Most common complaint of patients with multiple myeloma?
Bone pain (lower back pain)
infections
anemia
Hallmark of multiple myeloma?
monoclonal spikes on serum electrophoresis
bence-jones proteins
Most common congenital coagulopathy?
von Willebrand disease
What is Christmas disease?
Hemophilia B (Factor IX deficiency)
