Hematology Flashcards
Extracellular fluid
fluid existing outside of cells
Interstitial fluid
circulates within spaces between tissue cells
creates cell’s internal environment
Homeostasis
normal physiological boundaries
Functions of Blood
Transport- O, CO2, nutrients
Regulation- pH, temp
Protection- against blood loss and foreign toxins
Parts of Blood
plasma and formed elements
Components of Blood Plasma
90% H20, 10% solutes
proteins, nutrients, vitamins, hormones, electrolytes
Formed Elements
erythrocytes and leukocytes and platelets
Homopoiesis
making formed elements
in red bone marrow
Hemoglobin
transport oxygen and CO2
Erythropoiesis
making RBCs
Erythropoietin
stimulates erythropoiesis
made in kidneys and liver
Anemia
oxygen carrying capacity of blood is reduced through decreased number of RBCs or decreased concentration of hemoglobin
Anemia is a sign of…..
hemorrhage iron deficiency sickle cell (hemolytic anemia)
Leukopoiesis
Making WBCs
Colony Stimulating Factors
Interleukins
stimulates Leukopoiesis
White Blood Cell Functions
defend against pathogens
remove toxins and waste
attack abnormal cells
Neutrophils and Monocytes
fight inflammation and infection via phagocytes
Eosinophils
fight inflammation in allergic reaction, fight parasitic worms, and phagocytize
Basophils
fight inflammation in allergic reactions
Lymphocytes
T-cells (fungi, transplanted and cancer cells), B-cells (bacteria), NK cells (tumor cells)
Platelets
blood clotting
Formation of Platelets
requires thrombopoietin
Megakaryoblasts to Metamegakaryocytes to Platelets
Hemostasis
stopping bleeding
Phases of Hemostasis
Vascular Spasm
Platelet plug formation
Blood Clotting
Vascular Spasm
30 min
smooth muscle of vessel wall contracts to slow blood loss
Platelet Plug Formation
w/in 15 seconds after injury
platelets stick to exposed fibers and each other
Coagulation/ Blood Clotting
30 sec after injury
coagulation factors
fibrin traps formed elements which makes a clot
Requirements for Coagulation
Vit K- Liver to make clotting factors
Clot Retraction- pulls edges of damaged vessels closer together
Fibrinolysis- uses fibrinolysin to dissolve a clot