Haematology

Question 1

Cells present in blood film of coeliac?

Answer 1

Howell- Jolly bodies & Target cells

Question 2

AB for neutropenic sepsis?

Answer 2

Piperacillin with tazobactam (tazocin)

Question 3

What do you do for a cancer patient with a VTE?

Answer 3

6 months of DOAC (rivaroxaban)

Question 4

Starry sky pattern on lymph node biopsy?

Answer 4

Burkitt’s lymphoma subtype

Question 5

What drug offers benefits alongside chemo in patients with non-hodgkins?

Answer 5

Rituximan

Question 6

Prophylactic management of sickle cell anaemia?

Answer 6

Hydroxyurea

Question 7

Stage 1 of staging scale for Hodgkins lymphoma?

Answer 7

Stage1: Single lymph node
Ann-Arbor scale

Question 8

What is stage 2 H. Lymphoma?

Answer 8

2 or more lymph nodes/regions on same side of diaphragm

Question 9

Stage 3 ann arbor scale?

Answer 9

Nodes on both side of diaphragm

Question 10

Stage 4 of Ann ARbor scale?

Answer 10

Spread past lymph nodes

Question 11

What is thrombocytosis?

Answer 11

Abnormally high platelet count (>400)

Question 12

Causes of thrombocytosis?

Answer 12

Stress (surgery, iron deficiency)
Malignancy
Essential thrombocytosis
Hyposplenism

Question 13

Management of thrombocytosis?

Answer 13

Hydroxyurea
Interferon - a
Low dose aspirin

Question 14

Fever, chills, hypoT and back pain following blood transfusion?

Answer 14

Acute haemolytic reaction

Question 15

Management of Transfusion associated circulatory overload?

Answer 15

Slow rate of transfusion and give IV furosemide with O2

Question 16

Respiratory distress, HT, oedema following transfusion?

Answer 16

TACO

Question 17

Presentation of multiple myeloma?

Answer 17

CRABBI

-Calcium: hypercalcaemia
- Renal: Light chain deposition within renal tubules (dehydration and thirst)
- Anaemia:
- Bleeding: Pain, path fractures
-Infection: Reduction of normal immunoglobulins

Question 18

If fluids, analgesia and oxygen don’t help a patient in chest crisis what should you do?

Answer 18

Exchange transfusion

This reduces number of sickle red cells and increases number of normal red cells

Question 19

Which type of hodgkins lymphoma has the best prognosis?

Answer 19

Lymphocyte predominant

Question 20

Most common leukaemia in adults in western world?

Answer 20

Chronic lymphocytic leaukaemia

Question 21

Characteristics of CLL?

Answer 21

Peripheral blood lymphocytosis
Uncontrolled proliferation of small, mature lymphocytes in bone marrow, nodes and spleen

Question 22

Bacteria that is the most common cause of neutropenic sepsis?

Answer 22

S, Epidermis (assoc with central line infections)

Question 23

What is idarucizumab?

Answer 23

Reversal agent of dabigatran

Question 24

Most common inherited thrombophilia?

Answer 24

Activated protein C resistance factor (Factor V Leiden)

Question 25

Prolonged APTT?

Answer 25

VWB Disease

Question 26

What type of transfusion is anaphylaxis most common in?

Answer 26

Plasma rich blood products such as FFP, cryoprecitate and platelets

Question 27

Who gets acute intermittent prophyria?

Answer 27

Young women -Can be precipitated by ABs, hormonal contraception, barbiturates and seizure meds

Question 28

First line treatment of acute intermittent porphyria?

Answer 28

IV Haem arginate (acts to reduce the overproduction of delta- aminolevulnic acid)

Question 29

Preventative medication for tumour lysis syndrome?

Answer 29

IV rasburicase or IV Allopurinol

Question 30

First line treatment of polycythaemia vera?

Answer 30

Aspirin

Question 31

Which type of hodgkins lymphoma has the worst prognosis?

Answer 31

Lymphocyte depleted

Question 31

Treatment for women with past VTE and pregnancy?

Answer 31

Aspirin + LMWH

Question 31

Abdominal pain, constipation, neuropsychiatric features, basophilic stippling?

Answer 31

Lead poisoning

Question 32

Sudden anaemia + low reticulocyte count indicates what?

Answer 32

Parovirus

Question 33

Rate a unit of RBCs is usually transferred in a non-urgent scenario?

Answer 33

90-120 mins

Question 34

Unexplained petechiae or hepatosplenomegaly in 0-24 year old?

Answer 34

Special assessment for leukaemia

Question 35

How long should the treatment of an unprovoke VTE last?

Answer 35

6 months

Question 36

1st line InvgX for multiple myeloma?

Answer 36

Full body MRI

Question 37

Signs of poor prognosis for Hodgkin's Lymphoma?

Answer 37

Increasing age Male Stage IV disease Lymphocyte depleted subtype B symptoms

Question 38

Fever and chills following transfusion of packed RBCs, hypotensive + abdominal pain ?

Answer 38

Acute haemolytic transfusion reaction Stop transfusion, administer IV fluids

Question 39

AB of choice for neutropenic sepsis? + how that would present?

Answer 39

Tazocin Fever, rash, flue-like symptoms

Question 40

Chronic myeloid leukaemia treatment?

Answer 40

Imatinib

Question 41

Tear drop poilikocytes on blood film?

Answer 41

Myelofibrosis

Question 42

Features of aplastic anaemia?

Answer 42

Normocytic anaemia Leukoplania Thrombocytopenia

Question 43

What drug can cause aplastic anaemia?

Answer 43

Phenytoin

Question 44

If someone has a macrocytic anaemia and RA, what should be on your mind for the reasoning of this?

Answer 44

Methotrexate induced folate deficiency resulting in macrocytic anaemia

Question 45

What is Richter's transformation?

Answer 45

CLL transforms into more aggressive form of large cell lymphoma Development of B symptoms and diagnosed with lymph node biopsy

Question 46

What can myelodysplasia progress to?

Answer 46

Acute myeloid leukaemia

Question 47

How does Factor V Leiden increase someone's risk of VTE events?

Answer 47

Activated factor V is inactivated much more slowly by activated protein C

Question 48

What can malaria prophylaxis trigger?

Answer 48

Haemolytic Anaemia in people with G6PD deficiency

Question 49

Mycoplasma pneumonia followed by anaemia and juandice with hepatosplenomegaly points towards what diagnosis?

Answer 49

Cold AI haemolytic anaemia

Question 50

Man with Hb below 110g what should you always do?

Answer 50

Upper and Lower endoscopy with 2 week wait

Question 51

Pancytopenia 5 years post chemo?

Answer 51

Myelodysplastic syndrome

Question 52

How is transexamic acid given?

Answer 52

IV Bolus followed by slow infusion