Haematology Flashcards

1
Q

Cells present in blood film of coeliac?

A

Howell- Jolly bodies & Target cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

AB for neutropenic sepsis?

A

Piperacillin with tazobactam (tazocin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What do you do for a cancer patient with a VTE?

A

6 months of DOAC (rivaroxaban)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Starry sky pattern on lymph node biopsy?

A

Burkitt’s lymphoma subtype

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What drug offers benefits alongside chemo in patients with non-hodgkins?

A

Rituximan

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Prophylactic management of sickle cell anaemia?

A

Hydroxyurea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Stage 1 of staging scale for Hodgkins lymphoma?

A

Stage1: Single lymph node
Ann-Arbor scale

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is stage 2 H. Lymphoma?

A

2 or more lymph nodes/regions on same side of diaphragm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Stage 3 ann arbor scale?

A

Nodes on both side of diaphragm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Stage 4 of Ann ARbor scale?

A

Spread past lymph nodes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is thrombocytosis?

A

Abnormally high platelet count (>400)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Causes of thrombocytosis?

A

Stress (surgery, iron deficiency)
Malignancy
Essential thrombocytosis
Hyposplenism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Management of thrombocytosis?

A

Hydroxyurea
Interferon - a
Low dose aspirin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Fever, chills, hypoT and back pain following blood transfusion?

A

Acute haemolytic reaction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Management of Transfusion associated circulatory overload?

A

Slow rate of transfusion and give IV furosemide with O2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Respiratory distress, HT, oedema following transfusion?

A

TACO

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Presentation of multiple myeloma?

A

CRABBI

-Calcium: hypercalcaemia
- Renal: Light chain deposition within renal tubules (dehydration and thirst)
- Anaemia:
- Bleeding: Pain, path fractures
-Infection: Reduction of normal immunoglobulins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

If fluids, analgesia and oxygen don’t help a patient in chest crisis what should you do?

A

Exchange transfusion

This reduces number of sickle red cells and increases number of normal red cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Which type of hodgkins lymphoma has the best prognosis?

A

Lymphocyte predominant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Most common leukaemia in adults in western world?

A

Chronic lymphocytic leaukaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Characteristics of CLL?

A

Peripheral blood lymphocytosis
Uncontrolled proliferation of small, mature lymphocytes in bone marrow, nodes and spleen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Bacteria that is the most common cause of neutropenic sepsis?

A

S, Epidermis (assoc with central line infections)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What is idarucizumab?

A

Reversal agent of dabigatran

24
Q

Most common inherited thrombophilia?

A

Activated protein C resistance factor (Factor V Leiden)

25
Prolonged APTT?
VWB Disease
26
What type of transfusion is anaphylaxis most common in?
Plasma rich blood products such as FFP, cryoprecitate and platelets
27
Who gets acute intermittent prophyria?
Young women -Can be precipitated by ABs, hormonal contraception, barbiturates and seizure meds
28
First line treatment of acute intermittent porphyria?
IV Haem arginate (acts to reduce the overproduction of delta- aminolevulnic acid)
29
Preventative medication for tumour lysis syndrome?
IV rasburicase or IV Allopurinol
30
First line treatment of polycythaemia vera?
Aspirin
31
Which type of hodgkins lymphoma has the worst prognosis?
Lymphocyte depleted
31
Treatment for women with past VTE and pregnancy?
Aspirin + LMWH
31
Abdominal pain, constipation, neuropsychiatric features, basophilic stippling?
Lead poisoning
32
Sudden anaemia + low reticulocyte count indicates what?
Parovirus
33
Rate a unit of RBCs is usually transferred in a non-urgent scenario?
90-120 mins
34
Unexplained petechiae or hepatosplenomegaly in 0-24 year old?
Special assessment for leukaemia
35
How long should the treatment of an unprovoke VTE last?
6 months
36
1st line InvgX for multiple myeloma?
Full body MRI
37
Signs of poor prognosis for Hodgkin's Lymphoma?
Increasing age Male Stage IV disease Lymphocyte depleted subtype B symptoms
38
Fever and chills following transfusion of packed RBCs, hypotensive + abdominal pain ?
Acute haemolytic transfusion reaction Stop transfusion, administer IV fluids
39
AB of choice for neutropenic sepsis? + how that would present?
Tazocin Fever, rash, flue-like symptoms
40
Chronic myeloid leukaemia treatment?
Imatinib
41
Tear drop poilikocytes on blood film?
Myelofibrosis
42
Features of aplastic anaemia?
Normocytic anaemia Leukoplania Thrombocytopenia
43
What drug can cause aplastic anaemia?
Phenytoin
44
If someone has a macrocytic anaemia and RA, what should be on your mind for the reasoning of this?
Methotrexate induced folate deficiency resulting in macrocytic anaemia
45
What is Richter's transformation?
CLL transforms into more aggressive form of large cell lymphoma Development of B symptoms and diagnosed with lymph node biopsy
46
What can myelodysplasia progress to?
Acute myeloid leukaemia
47
How does Factor V Leiden increase someone's risk of VTE events?
Activated factor V is inactivated much more slowly by activated protein C
48
What can malaria prophylaxis trigger?
Haemolytic Anaemia in people with G6PD deficiency
49
Mycoplasma pneumonia followed by anaemia and juandice with hepatosplenomegaly points towards what diagnosis?
Cold AI haemolytic anaemia
50
Man with Hb below 110g what should you always do?
Upper and Lower endoscopy with 2 week wait
51
Pancytopenia 5 years post chemo?
Myelodysplastic syndrome
52
How is transexamic acid given?
IV Bolus followed by slow infusion
53