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Year 3 Revision > Gynae Cancer Pathology Info > Flashcards

Gynae Cancer Pathology Info Flashcards

1
Q

What is the commonly seen mutation in serous and clear cell endometrial carcinoma (type 2)?

A

TP53

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2
Q

What are the common mutations in endometrioid and mucinous endometrial cancer (type 1)?

A

PTEN
KRAS
PIK3CA

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3
Q

What type of gynae cancers is assoc with lynch syndrome/HNPCC?

A

Endometrioid carcinoma mainly

Also increased risk of ovarian and breast

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4
Q

What is the defect in lynch syndrome and what investigation looks for this?

A

Mutation of mismatch repair genes

Microsatellite instability

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5
Q

Out of type 1 and 2 endometrial carcinoma, which is more aggressive?

A

Type 2

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6
Q

Name the 6 types of epithelial ovarian tumour

A 
Serous
Mucinous
Endometrioid
Clear cell
Brenner
Undifferentiated carcinoma
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7
Q

What are the different precursors for high and low grade serous ovarian carcinoma?

A 
High grade (commonest) - serous tubal intraepithelial neoplasia
Low grade - serous borderline tumour
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8
Q

What 2 conditions are related to endometrioid carcinoma of the ovary?

A

Endometriosis

Lynch syndrome

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9
Q

Are endometrioid carcinomas of the uterus and ovary the same type of cancer?

A

Yes

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10
Q

What type of epithelium is in a brenner tumour?

A

Transitional epithelium

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11
Q

Are brenner tumours generally benign or malignant?

A

Benign mostly

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12
Q

What tumour of the ovary is equivalent to a seminoma of the testis?

A

Dysgerminoma

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13
Q

What are the 3 sex cord/stromal tumours of the ovary?

A

Fibroma/thecoma
Granulosa cell tumour
Sertoli-leydig cell tumours

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14
Q

What hormones can each of the 3 sex cord/stromal tumours produce?

A

Fibroma/thecoma - oestrogen
Granulosa cell tumour - oestrogen
Sertoli-leydig - androgens (duh)

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15
Q

Which of fibroma/thecoma and granulosa cell tumour are malignant?

A

Fibroma - benign

Granulosa - generally malignant

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16
Q

What are the commonest cancers to spread to the ovaries?

A

Stomach
Colon
Breast
Pancreas

17
Q

What is the precursor lesion of cervical adenocarcinoma?

A

Cervical glandular intraepithelial neoplasia (CGIN)

18
Q

Is cervical adenocarcinoma associated with HPV?

A

Yes

19
Q

CIN and cervical cancer risk factors

A

Persistent high risk HPV infection
Multiple sexual partners
Smoking
Immunocompromise

20
Q

Who tends to get vulvar intraepithelial neoplasia?

A

Young and older women

Older at greater risk of malignant progression

21
Q

Describe vulvar pagets disease

A

Crusting rash
Mucin containing cells in epidermis
Mostly no underlying cancer

22
Q

What is a Kruckenberg tumour?

A

Metastatic tumour from stomach to ovary

Signet ring histology

Year 3 Revision (70 decks)

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