Guillain-Barre Syndrome

Question 1

What is Guillain-Barre?

Answer 1

Immune mediates demyelination of peripheral nervous system

Question 2

What is the main trigger of Guillain-Barre?

Answer 2

Campylobacter Jejuni

Question 3

What are 2 other triggers?

Answer 3

Cytomegalovirus

Epstein-Barr virus

Question 4

What do B cells create antibodies against initially?

Answer 4

The pathogen

Question 5

What do these antibodies also match?

Answer 5

The proteins on the nerve cells

Question 6

What happens to the peripheral nerve cells

Answer 6

Demyelination

Question 7

What is the main presentation of Guillain Barre?

Answer 7

Progressive, symmetrical, ascending weakness of all limbs- starting at the feet

Question 8

What are the other symptoms of Gullian Barre?

Answer 8

Reduced reflexes
Neuropathic pain
Proximal muscles affected

Question 9

What proximal muscles are affected?

Answer 9

Respiratory

Cranial nerve- Facial weakness

Question 10

How long do symptoms take to develop after infetion?

Answer 10

4 weeks

Question 11

When do symptoms peak after infection?

Answer 11

2-4 weeks

Question 12

What is used in diagnosis?

Answer 12

Nerve conduction studies

Lumbar Puncture

Question 13

What will you see with nerve conduction studies?

Answer 13

Nerve conduction is slowed

Question 14

What will you see with lumbar puncture?

Answer 14

High protein

Normal white cell count

Question 15

What is the main management of Guillain-Barre?

Answer 15

IV immunoglobulins

Question 16

How would you treat a severe case with respiratory failure?

Answer 16

Intubation, Ventilation and admission to intensive care

Question 17

Patient presentation–

Answer 17

Progressive peripheral polyneuropathy with hyporeflexia

Patient presesnting with weakness in legs that is progressing upwards
Hyporeflexia
Normal sensation