Guillain-Barre Syndrome Flashcards

1
Q

What is Guillain-Barre?

A

Immune mediates demyelination of peripheral nervous system

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2
Q

What is the main trigger of Guillain-Barre?

A

Campylobacter Jejuni

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3
Q

What are 2 other triggers?

A

Cytomegalovirus

Epstein-Barr virus

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4
Q

What do B cells create antibodies against initially?

A

The pathogen

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5
Q

What do these antibodies also match?

A

The proteins on the nerve cells

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6
Q

What happens to the peripheral nerve cells

A

Demyelination

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7
Q

What is the main presentation of Guillain Barre?

A

Progressive, symmetrical, ascending weakness of all limbs- starting at the feet

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8
Q

What are the other symptoms of Gullian Barre?

A

Reduced reflexes
Neuropathic pain
Proximal muscles affected

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9
Q

What proximal muscles are affected?

A

Respiratory

Cranial nerve- Facial weakness

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10
Q

How long do symptoms take to develop after infetion?

A

4 weeks

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11
Q

When do symptoms peak after infection?

A

2-4 weeks

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12
Q

What is used in diagnosis?

A

Nerve conduction studies

Lumbar Puncture

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13
Q

What will you see with nerve conduction studies?

A

Nerve conduction is slowed

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14
Q

What will you see with lumbar puncture?

A

High protein

Normal white cell count

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15
Q

What is the main management of Guillain-Barre?

A

IV immunoglobulins

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16
Q

How would you treat a severe case with respiratory failure?

A

Intubation, Ventilation and admission to intensive care

17
Q

Patient presentation–

A

Progressive peripheral polyneuropathy with hyporeflexia

Patient presesnting with weakness in legs that is progressing upwards
Hyporeflexia
Normal sensation