Gross pathology hemolymph

Question 1

What causes an enlarged tonsil with hyperplastic change and centrally dilated lymphatics

Answer 1

Lymphangiomatous tonsillar polyp

Question 2

Tonsils with hemorrhage and necrosis in chickens

Answer 2

Newcastle disease (avian paramyxovirus type 1)

Question 3

What causes hemorrhage in the thymus?

Answer 3

Bromethalin (rodentacides), trauma, snake venom

Question 4

What causes thymic atrophy with dark fluid filled cysts in primates?

Answer 4

Viral or steroid induced cystic atrophy

Question 5

What causes small lymphoid organs w. hemorrhage/necrosis?

Answer 5

Virus (CSF)

Question 6

Paraneoplastic syndromes with thymoma

Answer 6

Exfoliative dermatitis
Paraneoplastic exophthalmos
Myasthenia gravis

Question 7

Which lymphoma is FeLV driven?

Answer 7

Thymic lymphoma

Question 8

Two presentations of lymphoma in ferrets

Answer 8

Young- visceral B cell
Older- large lymph nodes only, T cell

Question 9

Which mice get thymic lymphoma?

Answer 9

AKR (almost 100%), C57 and C58

Question 10

What cow breed gets congenital lymphedema?

Answer 10

Escher

Question 11

What causes congenital lymphedema

Answer 11

Podoplanin deficiency

Question 12

Cause of tiny, nonexistent LNs

Answer 12

SCID

Question 13

Cause of lymphoid necrosis in bursa (will be small)

Answer 13

Avian birnavirus (Infectious Bursal Disease); attacks B cells

Question 14

Cause of large bursa with edema; other gross lesion

Answer 14

Avian circovirus (Chicken Anemia Agent); attacks T cells, so also thymus atrophy

Question 15

Cause of enlarged LNs in a macaque

Answer 15

early SIV (lentivirus; loves lymphocytes)

Question 16

Cause of enlarged LNs in a pig

Answer 16

Porcine circovirus type 2

Question 17

Cause of enlarged LN in a dog

Answer 17

Dimorphic fungi- histoplasma, blastomyces
Coccidioidomycosis

Question 18

Cause of enlarged LN in cattle

Answer 18

Hairy vetch toxicity (vicia villosa)

Question 19

What kind of lymphoma is in cat GI?

Answer 19

T cell

Question 20

What kind of lymphoma is in the dog nose?

Answer 20

B cell

Question 21

What antigen is expressed on FeLV infected cells?

Answer 21

Feline oncovirus-associated cell membrane antigen (FOCMA)

Question 22

What type of lymphoma is caused by BLV

Answer 22

B cell

Question 23

Organs affected by BLV

Answer 23

Abomasum>heart>spinal cord>kidney>uterus

Question 24

What kind of lymphoma is most common the dog?

Answer 24

Diffuse large B cell

Question 25

What kind of lymphoma is only in 1 node, and is less aggressive?

Answer 25

T zone lymphoma

Question 26

What type of lymphoma is most common in the horse?

Answer 26

Alimentary T cell rich B cell lymphoma

Question 27

What is the cause of lymphoma in the mouse? What type?

Answer 27

Murine leukemia virus B cell from spleen

Question 28

Which rat strain gets lymphoma? What kind?

Answer 28

Fischer 344; large granular cell leukemia

Question 29

What causes lymphoma in guinea pigs?

Answer 29

Cavian leukemia

Question 30

What is the cause of lymphoma in hamsters?

Answer 30

Polyoma virus! not a retrovirus

Question 31

How do hamsters get polyoma virus?

Answer 31

transmitted through urine

Question 32

Where do rabbits get lymphoma?

Answer 32

kidneys

Question 33

Cause of lymphoma in baboons

Answer 33

Herpesvirus papio 1 (this is weird because 2 is usually the neoplasm causing one)

Question 34

Cause of lymphoma in new world monkeys

Answer 34

Herpes virus saimiri type 2 (this is how it usually is, 2 for tumor)

Question 35

Cause of lymphoma in macaques

Answer 35

SIV or lymphocrytpovirus (if immunosuppressed)

Question 36

What gross lesions are seen with Marek's disease (avian herpesvirus type 2)?

Answer 36

T cell follicular lymphoma (classic) Lymphocytic perineuritis of sciatic nerve (splay leg) Gray eye

Question 37

How to differentiate lymphoid leukosis from Marek's?

Answer 37

Viscera, bursa in an older bird- leukosis B cell or T cell

Question 38

Characteristic gross lesion with leukosis virus

Answer 38

Nakanuke feathering

Question 39

Foal with enlarged spleen and icterus, followed by hematomas and infarcts

Answer 39

Neonatal isoerythrolysis

Question 40

Tumor that older cats get in the spleen

Answer 40

Visceral mast cell tumor

Question 41

What tumor do cheetah's get in the spleen?

Answer 41

Myelolipoma

Question 42

Lentivirus effect on spleen

Answer 42

Initially, lymphoid hyperplasia, then lymphoid atrophy

Question 43

Cause of lymphoid hyperplasia in horse spleen

Answer 43

Equine Infectious Anemia

Question 44

Cause of lymphoid hyperplasia in a cat

Answer 44

FIV

Question 45

Macaque with spleen white pulp outlined by hemorrhage

Answer 45

Simian hemorrhagic fever (arterivirus)

Question 46

Cause of splenomegaly with hemorrhage and histiocytosis in pheasants, poultry

Answer 46

Marble Spleen Disease (Turkey adenovirus 3)

Question 47

Cat with fibrin on spleen

Answer 47

FIP

Question 48

Miliary (embolic) abscesses in the spleen of a cat

Answer 48

Francisella tularensis

Question 49

Difference between anaplasma marginale and babesia

Answer 49

Babesia is extravascular hemolysis, much worse clinically

Question 50

Icteric cat

Answer 50

Mycoplasma haemofelis

Question 51

Cause of bone marrow erythroid hyperplasia (dark red marrow) in horses

Answer 51

EIA (lentivirus)

Question 52

Three causes of bone marrow loss

Answer 52

Neoplasia Viral Nutritional deficiency

Question 53

Bone marrow appearance with chicken anemia virus (circovirus)

Answer 53

No erythroid precursors- pale bone marrow

Question 54

What causes nutritional marrow loss in chickens?

Answer 54

Folate deficiency

Question 55

Bone abscess in chickens cause

Answer 55

Enterococcus cecorum (sepsis)

Question 56

Signs seen with multiple myeloma

Answer 56

Boney resorption due to osteoclast activation Monoclonal gammopathy Bence Jones proteins in urine Hypercalcemia (from osteoclasts) Cytoplenias due to replacement