Gross Pathology of Respiratory System 2

Question 1

What type of lymphoma occurs in the nasal cavity of cats?

Answer 1

B cell lymphoma

Question 2

Granular Cell Tumor features

Answer 2

Horse lung, dog larynx, rat brain, diastase resistant (granules are mitochondria, not glycogen)

Question 3

What do A strain mice get?

Answer 3

Tumors in general due to activation of K-RAS oncogene, specifically pulmonary adenocarcinoma

Question 4

Hemangiosarcoma locations in dog

Answer 4

1. Right atrium
   Lung, liver, spleen

Question 5

Bloody nose syndrome in macaques is caused by

Answer 5

Moraxella macacae

Question 6

Three causes of Glasser’s disease (polyserositis)

Answer 6

Glaesserella parasuis
Streptococcus suis
Mycoplasma hyorhinis

Question 7

Causes of nasal abscesses in cattle

Answer 7

Trueperella pyogenes
Fusobacterium necrophorum

Question 8

Causative agent of Strangles; most likely location

Answer 8

Streptococcus equi sub. equi; submandibular LN, bastard strangles if not head/neck

Question 9

What causes progressive atrophic rhinitis in pigs? nonprogressive?

Typical age range?

Answer 9

Progressive:
Pasteurella multocida type D toxin (dermonecrotizing toxin)
Bordetella bronchiseptica

Nonprogressive:
Bordetella

Age: 8-12 weeks

Question 10

What causes atrophic rhinitis in rabbits?

Answer 10

Bordetella bronchiseptica
Pasteurella multocida?

Question 11

Agent and name for necrotic rhinitis in swine

Answer 11

Fusobacterium necrophorum; Bullnose

Question 12

Cause of chronic proliferative rhinitis in sheep

Answer 12

Salmonella enterica subs. diarizonae

Question 13

Causative agent of guttural pouch empyema/eustachitis

Answer 13

Strep equi sub equi, later colonized by strep equi sub zooepidemicus

Question 14

Gross finding with infectious coryza?

Answer 14

infraorbital sinus distension, facial edema, URI

Avibacterium paragallinarum

Question 15

Causative agent of Infectious Coryza in poultry

Answer 15

Avibacterium paragallinarum

Question 16

Turkeys with soft swollen head have…

Answer 16

Avian pneumovirus

Question 17

Poultry with hard swellings of the infraorbital sinuses have…

Answer 17

Mycoplasma gallisepticum; infectious sinusitis

Question 18

Sparrows and birds with infectious sinusitis or chronic respiratory disease

Answer 18

Mycoplasma gallisepticum

Question 19

What causes turkey coryza? unique feature of this bacteria?

Answer 19

Bordetella avium; infectious sinusitis, blepharitis, conjunctivitis, submandibular edema; lysis of tracheal rings (chondromalacia) due to cytotoxin

Question 20

Causes soap bubble lesions in air sacs and sinuses of turkeys

Answer 20

Mycoplasma meleagridis

Question 21

Causes suppurative air sacculitis in NHPs (2)

Answer 21

Klebsiella pneumoniae
Streptococcus pneumoniae

Question 22

Causes necrotic laryngitis in young cattle (aka calf diphtheria) (2)

Answer 22

Fusobacterium necrophorum
Histophilus somni

Question 23

Gram negative bacteria

Answer 23

Bordetella bronchiseptica
Escherichia coli
Klebsiella pneumoniae
Pasteurella multocida
Francisella tularensis
Mannheimia hemolytica

Question 24

Gram positive bacteria

Answer 24

Staph
Strep

Question 25

What agent causes severe bronchopneumonia with hemorrage and necrosis in guinea pigs?

Answer 25

Bordetella bronchiseptica

Question 26

Bordetella bronchiseptica virulence factors

Answer 26

RTX toxin Dermonecrotic toxin Adherence factors (hemagglutinin) Fimbriae

Question 27

Agent that causes big ugly hemorrhagic leaky lungs in the dog

Answer 27

Extra intestinal pathogenic E.coli (ExPEC) Streptococcus canis Streptococcus equi subs. zooepidemicus Salmonella Not bordetella, would be collapsed

Question 28

E.coli virulence factors

Answer 28

Cytotoxic necrotizing factor 1 Fimbriae Hemolysins Adhesins

Question 29

Francisella tularensis causes what gross lesions in the cat?

Answer 29

Splenic necrosis Peyer's patch and mesenteric LN necrosis Embolic pneumonia (multifocal to coalescing suppurative embolic pneumonia)

Question 30

Diffuse, chronic, proliferative, suppurative pyothorax (ragu) in cat or dog chest

Answer 30

Actinomyces (will see sulfur granules) Nocardia asteroides- no sulfur granules, weakly acid fast

Question 31

What causes "snuffles" in rabbits? Ddx?

Answer 31

Pasteurella multocida; staphylococcus aureus

Question 32

Gross findings with staphylococcus aureus in rabbits

Answer 32

Creamy white exudate, necrotic lymph nodes, abscesses in lungs and viscera

Question 33

Shipping fever of NHPs

Answer 33

Klebsiella pneumoniae

Question 34

Fibrin in cavities of a NHP (Fibrinosuppurative meningitis, bronchopneumonia, etc.)

Answer 34

Streptococcus pneumoniae

Question 35

Lung abscess in a mouse- differentials?

Answer 35

Pasteurella pneumotropica, streptobacillus moniliformis, staph, corynebacterium kutscheri

Question 36

Morphologic diagnosis for mycoplasma pulmonis in mice and rats? Virulence factors?

Answer 36

Suppurative bronchopneumonia with bronchiectasis Superantigen- BALT hyperplasia

Question 37

How to differentiate mycoplasma pulmonis and corynebacterium kutscheri grossly in mouse or rat?

Answer 37

Corynebacterium will affect all lungs, because hematogenous

Question 38

How to differentiate mycoplasma pulmonis and filobacterium rodentium grossly in mouse or rat?

Answer 38

Can't grossly, same lesions. On histo, will see filamentous bacteria with filobacterium

Question 39

Morphologic diagnosis for rhodococcus equi in 1-6 month foal?

Answer 39

Multifocal to coalescing granulomatous pneumonia

Question 40

Six agents involved in Shipping Fever in cattle

Answer 40

1. Pasteurella multocida 2. Bibersteinia trehalosi 3. Mannheima hemolytica (classic) 4. Histophilus somni 5. Mycoplasma mycoides SCT 6. Mycoplasma bovis

Question 41

Virulence factors associated with mannheimia hemolytica

Answer 41

Endotoxin Polysaccharide capsule RTX toxin- oat cells leukocytotoxic

Question 42

Gross lesions associated with Shipping Fever in cattle

Answer 42

Cranioventral suppurative bronchopneumonia with bronchiectasis and fibrinous pleuritis

Question 43

How does mycoplasma mycoides subsp. mycoides look different than shipping fever?

Answer 43

Unilateral

Question 44

What causes caseous lymphadenitis in small ruminants?

Answer 44

Corynebacterium pseudotuberculosis

Question 45

What causes enzootic pneumonia in grower/finisher pigs?

Answer 45

Mycoplasma hyopneumoniae

Question 46

Three causes of fibrinous polyserositis in pigs?

Answer 46

Streptococcus suis Glaesserella parasuis Mycoplasma hyorhinis

Question 47

Worst pneumonia in pigs

Answer 47

Actinobacillus pleuropneumoniae

Question 48

Pig pneumonia that can become sepsis

Answer 48

Actinobacillus suis

Question 49

Agents that cause pneumonia and sepsis in poultry

Answer 49

Pasteurella multocida Ornithobacterium rhinotracheale

Question 50

Causes soap bubble exudate within mesentery of turkeys

Answer 50

Mycoplasma meleagridis