Glycoconjugates MCDB108 A

Question 1

sugars attached to proteins make _______

Answer 1

glycoproteins/ proteoglycans

Question 2

sugars attached to lipids make _______

Answer 2

glycolipids

Question 3

glycoconjugates are synthesized in the _______ and ________

Answer 3

ER, golgi apparatus

Question 4

proteoglycans help create the _________ matrix, mediate cell-cell _____ and diversify signaling pathways

Answer 4

extracellular, adhesion

Question 5

_____ have carbohydrate binding domains that read the sugar code

Answer 5

lectins

Question 6

proteoglycans have ________ being the larger component by weight

Answer 6

carbohydrates

Question 7

glycoproteins have _______ being the larger component by weight

Answer 7

proteins

Question 8

glycosaminoglycans (GAG) have linear repats of ________

Answer 8

disaccharides

Question 9

repeating disaccharides in GAGs are highly ______ charged

Answer 9

negatively

Question 10

negative charge leads to extended, hydrated molecules wit high volume/mass ration that form gels at low concentrations which act as ______ ______

Answer 10

shock absorbers

Question 11

________ are heavily glycosylated proteins (80% carb) that work as lubricants and __________ barriers.

Answer 11

mucins, protective

Question 12

antibodies have defined _____ essential for their function

Answer 12

glycans

Question 13

glycosylation of antigens impedes ________ recognition

Answer 13

immune

Question 14

in the ER a pre built ______ core is built onto a lipid and transferred to _____ residues

Answer 14

saccharide, asparagine

Question 15

glycans in the ER contribute to _____ folding and ______ control

Answer 15

protein, quality

Question 16

in the golgi new _____ can be added to serine/threonines, glycans are made more ______, and proteins are sorted to _______

Answer 16

glycans, complex, destination

Question 17

the golgi harbors many glycosyl transferases which modify N and O linked glycans into complex _______ ideal for signaling

Answer 17

sugars

Question 18

glycolipids are also modified in the _____ and _____

Answer 18

ER, golgi

Question 19

a _________ has 1-7 sugars attached to a sphingolipid, and is only found on the extracellular leaflet. it is made in the golgi

Answer 19

cerebroside

Question 20

blood ABO groups are determined by absence/presence of _________ transferases

Answer 20

glycosyl

Question 21

different ________ attached to proteins and lipids on the surface of red blood cells distinguish one blood group from another

Answer 21

carbohydrates

Question 22

the glycans on glycoproteins are recognized by _______ which are specialized proteins that bind _________

Answer 22

lectins, carbohydrates

Question 23

lectin receptor site structure dictates ________ by h bonding to hydroxyls, hydrophobic interactions with CH, shape, and sterics

Answer 23

selectivity

Question 24

acid hydrolysis helps break ________ bonds

Answer 24

glycosidic

Question 25

modification of open hydroxyls before acid hydrolysis using methyl iodide shows ______ involved in __________ linkages.

Answer 25

carbons, glycosidic

Question 26

sensitivity to endoglycosdiase H is a marker of ______ along the ______ pathway

Answer 26

progression, secretory